{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kolarova TR"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","NHLBI Division of Intramural Research","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["456-458"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922755"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["143(3)"],"pubmed_abstract":["Uterine leiomyomas may affect the performance of cell-free DNA (cfDNA)-based noninvasive prenatal testing (NIPT). We conducted a retrospective cohort study of pregnant individuals with and without leiomyomas undergoing first-trimester cfDNA-based NIPT. Characteristics of NIPT in patients with leiomyomas (n=122) were compared with those in patients without leiomyomas (n=937). Mean fetal fraction was lower in patients with leiomyomas compared with patients without (10.0% vs 11.5%; P =.001); however, the rate of indeterminate results was different only in patients without obesity (body mass index [BMI] lower than 30) (5.3% vs 1.5%; P =0.03). Total cfDNA concentration was higher in patients with leiomyomas ( P =.002), suggesting possible dilution of the fetal fraction. Leiomyoma size did not affect NIPT metrics. In conclusion, uterine leiomyomas are associated with lower fetal fraction and, in patients without obesity, with a higher rate of indeterminate results independent of leiomyoma size."],"journal":["Obstetrics and gynecology"],"pubmed_title":["Effect of Uterine Leiomyomas on Noninvasive Prenatal Testing Parameters in the First Trimester."],"pmcid":["PMC10922755"],"funding_grant_id":["K08 HL150169","K08HL150169","T32 GM007454","UL1 TR002319"],"pubmed_authors":["Buchan JG","Lockwood C","MacKinnon H","Chen L","Kolarova TR","Shree R","Alderson A"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Uterine Leiomyomas on Noninvasive Prenatal Testing Parameters in the First Trimester.","description":"Uterine leiomyomas may affect the performance of cell-free DNA (cfDNA)-based noninvasive prenatal testing (NIPT). We conducted a retrospective cohort study of pregnant individuals with and without leiomyomas undergoing first-trimester cfDNA-based NIPT. Characteristics of NIPT in patients with leiomyomas (n=122) were compared with those in patients without leiomyomas (n=937). Mean fetal fraction was lower in patients with leiomyomas compared with patients without (10.0% vs 11.5%; P =.001); however, the rate of indeterminate results was different only in patients without obesity (body mass index [BMI] lower than 30) (5.3% vs 1.5%; P =0.03). Total cfDNA concentration was higher in patients with leiomyomas ( P =.002), suggesting possible dilution of the fetal fraction. Leiomyoma size did not affect NIPT metrics. In conclusion, uterine leiomyomas are associated with lower fetal fraction and, in patients without obesity, with a higher rate of indeterminate results independent of leiomyoma size.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T19:26:25.538Z","creation":"2025-04-04T19:26:25.538Z"},"accession":"S-EPMC10922755","cross_references":{"pubmed":["38207338"],"doi":["10.1097/aog.0000000000005504","10.1097/AOG.0000000000005504"]}}