{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang WA"],"funding":["NIMH","NIMH NIH HHS","University of North Carolina Wilmington","National Institutes of Health"],"pagination":["727-739.e5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922762"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(4)"],"pubmed_abstract":["Sustained visual attention allows us to process and react to unpredictable, behaviorally relevant sensory input. Sustained attention engages communication between the higher-order visual thalamus and its connected cortical regions. However, it remains unclear whether there is a causal relationship between oscillatory circuit dynamics and attentional behavior in these thalamo-cortical circuits. By using rhythmic optogenetic stimulation in the ferret, we provide causal evidence that higher-order visual thalamus coordinates thalamo-cortical and cortico-cortical functional connectivity during sustained attention via spike-field phase locking. Increasing theta but not alpha power in the thalamus improved accuracy and reduced omission rates in a sustained attention task. Further, the enhancement of effective connectivity by stimulation was correlated with improved behavioral performance. Our work demonstrates a potential circuit-level causal mechanism for how the higher-order visual thalamus modulates cortical communication through rhythmic synchronization during sustained attention."],"journal":["Current biology : CB"],"pubmed_title":["Causal oscillations in the visual thalamo-cortical network in sustained attention in ferrets."],"pmcid":["PMC10922762"],"funding_grant_id":["R01 MH124387","R01MH122477","F31 MH118799","R01 MH111889","F31MH118799","R01MH111889","R01MH124387","R01 MH122477"],"pubmed_authors":["Stitt IM","Radtke-Schuller S","Frohlich F","Huang WA","Ramasamy NS","Zhou ZC"],"additional_accession":[]},"is_claimable":false,"name":"Causal oscillations in the visual thalamo-cortical network in sustained attention in ferrets.","description":"Sustained visual attention allows us to process and react to unpredictable, behaviorally relevant sensory input. Sustained attention engages communication between the higher-order visual thalamus and its connected cortical regions. However, it remains unclear whether there is a causal relationship between oscillatory circuit dynamics and attentional behavior in these thalamo-cortical circuits. By using rhythmic optogenetic stimulation in the ferret, we provide causal evidence that higher-order visual thalamus coordinates thalamo-cortical and cortico-cortical functional connectivity during sustained attention via spike-field phase locking. Increasing theta but not alpha power in the thalamus improved accuracy and reduced omission rates in a sustained attention task. Further, the enhancement of effective connectivity by stimulation was correlated with improved behavioral performance. Our work demonstrates a potential circuit-level causal mechanism for how the higher-order visual thalamus modulates cortical communication through rhythmic synchronization during sustained attention.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-04T10:42:09.173Z","creation":"2025-04-04T10:42:09.173Z"},"accession":"S-EPMC10922762","cross_references":{"pubmed":["38262418"],"doi":["10.1016/j.cub.2023.12.067"]}}