biostudies-literatureGomez-Campo KPennsylvania State UniversityNational Institutes of HealthNIGMS NIH HHSNIH HHSNational Science Foundatione17246https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922902biostudies-literatureUnknown33(4)Acclimatization through phenotypic plasticity represents a more rapid response to environmental change than adaptation and is vital to optimize organisms' performance in different conditions. Generally, animals are less phenotypically plastic than plants, but reef-building corals exhibit plant-like properties. They are light dependent with a sessile and modular construction that facilitates rapid morphological changes within their lifetime. We induced phenotypic changes by altering light exposure in a reciprocal transplant experiment and found that coral plasticity is a colony trait emerging from comprehensive morphological and physiological changes within the colony. Plasticity in skeletal features optimized coral light harvesting and utilization and paralleled significant methylome and transcriptome modifications. Network-associated responses resulted in the identification of hub genes and clusters associated to the change in phenotype: inter-partner recognition and phagocytosis, soft tissue growth and biomineralization. Furthermore, we identified hub genes putatively involved in animal photoreception-phototransduction. These findings fundamentally advance our understanding of how reef-building corals repattern the methylome and adjust a phenotype, revealing an important role of light sensing by the coral animal to optimize photosynthetic performance of the symbionts.Molecular ecologyPhenotypic plasticity for improved light harvesting, in tandem with methylome repatterning in reef-building corals.PMC10922902NIH R01 GM134056‐01NSF OCE‐1537959R01 GM134056NIH R01 GM134056-01Yang XGomez-Campo KSanchez REnriquez SIglesias-Prieto RBaums IBMaher TMartinez-Rugerio IOsborne CCMackenzie SAfalsePhenotypic plasticity for improved light harvesting, in tandem with methylome repatterning in reef-building corals.Acclimatization through phenotypic plasticity represents a more rapid response to environmental change than adaptation and is vital to optimize organisms' performance in different conditions. Generally, animals are less phenotypically plastic than plants, but reef-building corals exhibit plant-like properties. They are light dependent with a sessile and modular construction that facilitates rapid morphological changes within their lifetime. We induced phenotypic changes by altering light exposure in a reciprocal transplant experiment and found that coral plasticity is a colony trait emerging from comprehensive morphological and physiological changes within the colony. Plasticity in skeletal features optimized coral light harvesting and utilization and paralleled significant methylome and transcriptome modifications. Network-associated responses resulted in the identification of hub genes and clusters associated to the change in phenotype: inter-partner recognition and phagocytosis, soft tissue growth and biomineralization. Furthermore, we identified hub genes putatively involved in animal photoreception-phototransduction. These findings fundamentally advance our understanding of how reef-building corals repattern the methylome and adjust a phenotype, revealing an important role of light sensing by the coral animal to optimize photosynthetic performance of the symbionts.2024-01-01T00:00:00Z2024 Feb2026-06-01T18:11:49.316Z2025-04-05T19:20:06.47ZS-EPMC109229023815317710.1111/mec.17246