{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brown BL"],"funding":["NINDS NIH HHS","NIH"],"pagination":["114631"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922963"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["373"],"pubmed_abstract":["Long ascending propriospinal neurons (LAPNs) are a subset of spinal interneurons that provide direct connectivity between distant spinal segments. Here, we focus specifically on an anatomically defined population of \"inter-enlargement\" LAPNs with cell bodies at L2/3 and terminals at C5/6. Previous studies showed that silencing LAPNs in awake and freely moving animals disrupted interlimb coordination of the hindlimbs, forelimbs, and heterolateral limb pairs. Surprisingly, despite a proportion of LAPNs being anatomically intact post- spinal cord injury (SCI), silencing them improved locomotor function but only influenced coordination of the hindlimb pair. Given the functional significance of LAPNs pre- and post-SCI, we characterized their anatomy and SCI-induced anatomical plasticity. This detailed anatomical characterization revealed three morphologically distinct subsets of LAPNs that differ in soma size, neurite complexity and/or neurite orientation. Following a mild thoracic contusive SCI there was a marked shift in neurite orientation in two of the LAPN subsets to a more dorsoventral orientation, and collateral densities decreased in the cervical enlargement but increased just caudal to the injury epicenter. These post-SCI anatomical changes potentially reflect maladaptive plasticity and an effort to establish new functional inputs from sensory afferents that sprout post-SCI to achieve circuitry homeostasis."],"journal":["Experimental neurology"],"pubmed_title":["Long ascending propriospinal neurons are heterogenous and subject to spinal cord injury induced anatomic plasticity."],"pmcid":["PMC10922963"],"funding_grant_id":["R01 NS112304","F31 NS116935"],"pubmed_authors":["Anil N","States G","Brown BL","Whittemore SR","Magnuson DSK"],"additional_accession":[]},"is_claimable":false,"name":"Long ascending propriospinal neurons are heterogenous and subject to spinal cord injury induced anatomic plasticity.","description":"Long ascending propriospinal neurons (LAPNs) are a subset of spinal interneurons that provide direct connectivity between distant spinal segments. Here, we focus specifically on an anatomically defined population of \"inter-enlargement\" LAPNs with cell bodies at L2/3 and terminals at C5/6. Previous studies showed that silencing LAPNs in awake and freely moving animals disrupted interlimb coordination of the hindlimbs, forelimbs, and heterolateral limb pairs. Surprisingly, despite a proportion of LAPNs being anatomically intact post- spinal cord injury (SCI), silencing them improved locomotor function but only influenced coordination of the hindlimb pair. Given the functional significance of LAPNs pre- and post-SCI, we characterized their anatomy and SCI-induced anatomical plasticity. This detailed anatomical characterization revealed three morphologically distinct subsets of LAPNs that differ in soma size, neurite complexity and/or neurite orientation. Following a mild thoracic contusive SCI there was a marked shift in neurite orientation in two of the LAPN subsets to a more dorsoventral orientation, and collateral densities decreased in the cervical enlargement but increased just caudal to the injury epicenter. These post-SCI anatomical changes potentially reflect maladaptive plasticity and an effort to establish new functional inputs from sensory afferents that sprout post-SCI to achieve circuitry homeostasis.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T19:26:23.662Z","creation":"2025-04-04T19:26:23.662Z"},"accession":"S-EPMC10922963","cross_references":{"pubmed":["38070723"],"doi":["10.1016/j.expneurol.2023.114631"]}}