{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wahl N"],"funding":["Irish Research Council","Austrian Science Fund FWF","NIMH NIH HHS","National Institutes of Health"],"pagination":["621-639.e9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10923151"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["84(4)"],"pubmed_abstract":["The DNA-binding protein SATB2 is genetically linked to human intelligence. We studied its influence on the three-dimensional (3D) epigenome by mapping chromatin interactions and accessibility in control versus SATB2-deficient cortical neurons. We find that SATB2 affects the chromatin looping between enhancers and promoters of neuronal-activity-regulated genes, thus influencing their expression. It also alters A/B compartments, topologically associating domains, and frequently interacting regions. Genes linked to SATB2-dependent 3D genome changes are implicated in highly specialized neuronal functions and contribute to cognitive ability and risk for neuropsychiatric and neurodevelopmental disorders. Non-coding DNA regions with a SATB2-dependent structure are enriched for common variants associated with educational attainment, intelligence, and schizophrenia. Our data establish SATB2 as a cell-type-specific 3D genome modulator, which operates both independently and in cooperation with CCCTC-binding factor (CTCF) to set up the chromatin landscape of pyramidal neurons for cognitive processes."],"journal":["Molecular cell"],"pubmed_title":["SATB2 organizes the 3D genome architecture of cognition in cortical neurons."],"pmcid":["PMC10923151"],"funding_grant_id":["R01MH117790","FWF-P32850-B","FWF-P33027-B","R01 MH117790","P 32850","RCS1730","FWF-DK W1206"],"pubmed_authors":["Wahl N","Espeso-Gil S","Morris DW","Dechant G","Laighneach A","Apostolova G","Nagel A","Chietera P","Akbarian S","Rajarajan P"],"additional_accession":[]},"is_claimable":false,"name":"SATB2 organizes the 3D genome architecture of cognition in cortical neurons.","description":"The DNA-binding protein SATB2 is genetically linked to human intelligence. We studied its influence on the three-dimensional (3D) epigenome by mapping chromatin interactions and accessibility in control versus SATB2-deficient cortical neurons. We find that SATB2 affects the chromatin looping between enhancers and promoters of neuronal-activity-regulated genes, thus influencing their expression. It also alters A/B compartments, topologically associating domains, and frequently interacting regions. Genes linked to SATB2-dependent 3D genome changes are implicated in highly specialized neuronal functions and contribute to cognitive ability and risk for neuropsychiatric and neurodevelopmental disorders. Non-coding DNA regions with a SATB2-dependent structure are enriched for common variants associated with educational attainment, intelligence, and schizophrenia. Our data establish SATB2 as a cell-type-specific 3D genome modulator, which operates both independently and in cooperation with CCCTC-binding factor (CTCF) to set up the chromatin landscape of pyramidal neurons for cognitive processes.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-03T04:49:04.303Z","creation":"2025-07-11T03:04:07.402Z"},"accession":"S-EPMC10923151","cross_references":{"pubmed":["38244545"],"doi":["10.1016/j.molcel.2023.12.024"]}}