{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Farsijani S"],"funding":["National Center for Advancing Translational Sciences","National Institute of Arthritis and Musculoskeletal and Skin Diseases","Pittsburgh Older Americans Independence Center Scholar","NCATS NIH HHS","NIA NIH HHS","National Institutes of Health","NIAMS NIH HHS","National Institute on Aging","NIH HHS"],"pagination":["glae030"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10924448"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(4)"],"pubmed_abstract":["<h4>Background</h4>Gut dysbiosis has been linked to frailty, but its association with early mobility decline is unclear.<h4>Methods</h4>First, we determined the cross-sectional associations between walking speed and the gut microbiome in 740 older men (84 ± 4 years) from the MrOS cohort with available stool samples and 400 m walking speed measured in 2014-2016. Then, we analyzed the retrospective longitudinal associations between changes in 6 m walking speed (from 2005-2006 to 2014-2016, calculated by simple linear equation) and gut microbiome composition among participants with available data (702/740). We determined gut microbiome composition by 16S sequencing and examined diversity, taxa abundance, and performed network analysis to identify differences in the gut microbiome network of fast versus slow walkers.<h4>Results</h4>Faster 400 m walking speed (m/s) was associated with greater microbiome α-diversity (R = 0.11; p = .004). The association between a slower decline in 6 m walking speed and higher α-diversity (R = 0.07; p = .054) approached borderline significance. Faster walking speed and less decline in walking speed were associated with a higher abundance of genus-level bacteria that produce short-chain fatty acids, and possess anti-inflammatory properties, including Paraprevotella, Fusicatenibacter, and Alistipes, after adjusting for potential covariates (p < .05). The gut microbiome networks of participants in the first versus last quartile of walking speed (≤0.9 vs ≥1.2 m/s) exhibited distinct characteristics, including different centrality measures (p < .05).<h4>Conclusions</h4>Our findings suggest a possible relationship between gut microbiome diversity and mobility function, as indicated by the associations between faster walking speed and less decline in walking speed over 10 years with higher gut microbiome diversity in older men."],"journal":["The journals of gerontology. Series A, Biological sciences and medical sciences"],"pubmed_title":["Associations Between Walking Speed and Gut Microbiome Composition in Older Men From the MrOS Study."],"pmcid":["PMC10924448"],"funding_grant_id":["R01 AR061445","U01 AG042139","U01 AG042168","U01 AG042124","P30AG024827","U01 AG042145","P30 AG024827","UL1 TR002369","U01 AG042143","U01 AG027810","U01 AG042140","R01 AG066671","U01 AR066160","K01 AG071855"],"pubmed_authors":["Orwoll ES","Farsijani S","Kado DM","Kiel DP","Langsetmo L","Cauley JA","Newman AB","Cawthon PM"],"additional_accession":[]},"is_claimable":false,"name":"Associations Between Walking Speed and Gut Microbiome Composition in Older Men From the MrOS Study.","description":"<h4>Background</h4>Gut dysbiosis has been linked to frailty, but its association with early mobility decline is unclear.<h4>Methods</h4>First, we determined the cross-sectional associations between walking speed and the gut microbiome in 740 older men (84 ± 4 years) from the MrOS cohort with available stool samples and 400 m walking speed measured in 2014-2016. Then, we analyzed the retrospective longitudinal associations between changes in 6 m walking speed (from 2005-2006 to 2014-2016, calculated by simple linear equation) and gut microbiome composition among participants with available data (702/740). We determined gut microbiome composition by 16S sequencing and examined diversity, taxa abundance, and performed network analysis to identify differences in the gut microbiome network of fast versus slow walkers.<h4>Results</h4>Faster 400 m walking speed (m/s) was associated with greater microbiome α-diversity (R = 0.11; p = .004). The association between a slower decline in 6 m walking speed and higher α-diversity (R = 0.07; p = .054) approached borderline significance. Faster walking speed and less decline in walking speed were associated with a higher abundance of genus-level bacteria that produce short-chain fatty acids, and possess anti-inflammatory properties, including Paraprevotella, Fusicatenibacter, and Alistipes, after adjusting for potential covariates (p < .05). The gut microbiome networks of participants in the first versus last quartile of walking speed (≤0.9 vs ≥1.2 m/s) exhibited distinct characteristics, including different centrality measures (p < .05).<h4>Conclusions</h4>Our findings suggest a possible relationship between gut microbiome diversity and mobility function, as indicated by the associations between faster walking speed and less decline in walking speed over 10 years with higher gut microbiome diversity in older men.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-04T00:08:38.961Z","creation":"2025-04-04T00:08:38.961Z"},"accession":"S-EPMC10924448","cross_references":{"pubmed":["38271209"],"doi":["10.1093/gerona/glae030"]}}