biostudies-literatureYe RNatural Science Foundation of Jiangxi ProvinceNatural Science Foundation of Jiangxi Province (Jiangxi Province Natural Science Foundation)National Natural Science Foundation of ChinaNational Natural Science Foundation of China (National Science Foundation of China)2159https://www.ebi.ac.uk/biostudies/studies/S-EPMC10924954biostudies-literatureUnknown15(1)CO₂ hydrogenation to chemicals and fuels is a significant approach for achieving carbon neutrality. It is essential to rationally design the chemical structure and catalytic active sites towards the development of efficient catalysts. Here we show a Ce-CuZn catalyst with enriched Cu/Zn-O_V-Ce active sites fabricated through the atomic-level substitution of Cu and Zn into Ce-MOF precursor. The Ce-CuZn catalyst exhibits a high methanol selectivity of 71.1% and a space-time yield of methanol up to 400.3 g·kg_cat^-1·h^-1 with excellent stability for 170 h at 260 °C, comparable to that of the state-of-the-art CuZnAl catalysts. Controlled experiments and DFT calculations confirm that the incorporation of Cu and Zn into CeO₂ with abundNature communicationsA Ce-CuZn catalyst with abundant Cu/Zn-O_V-Ce active sites for CO₂ hydrogenation to methanol.PMC1092495422005296U23A2013220232ACB213001;20224BAB213015Liu JDuyar MSMa LWang BMa YZhang RMao JJiang ZGallo AHong XYe RLuo WWang XfalseA Ce-CuZn catalyst with abundant Cu/Zn-O_V-Ce active sites for CO₂ hydrogenation to methanol.CO₂ hydrogenation to chemicals and fuels is a significant approach for achieving carbon neutrality. It is essential to rationally design the chemical structure and catalytic active sites towards the development of efficient catalysts. Here we show a Ce-CuZn catalyst with enriched Cu/Zn-O_V-Ce active sites fabricated through the atomic-level substitution of Cu and Zn into Ce-MOF precursor. The Ce-CuZn catalyst exhibits a high methanol selectivity of 71.1% and a space-time yield of methanol up to 400.3 g·kg_cat^-1·h^-1 with excellent stability for 170 h at 260 °C, comparable to that of the state-of-the-art CuZnAl catalysts. Controlled experiments and DFT calculations confirm that the incorporation of Cu and Zn into CeO₂ with abund2024-01-01T00:00:00Z2024 Mar2025-04-04T12:58:32.243Z2025-04-04T12:58:32.243ZS-EPMC109249543846131510.1038/s41467-024-46513-3