{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Mulholland HN"],"funding":["NEI NIH HHS","NIMH NIH HHS"],"pubmed_abstract":["During development, cortical activity is organized into distributed modular patterns that are a precursor of the mature columnar functional architecture. Theoretically, such structured neural activity can emerge dynamically from local synaptic interactions through a recurrent network with effective local excitation with lateral inhibition (LE/LI) connectivity. Utilizing simultaneous widefield calcium imaging and optogenetics in juvenile ferret cortex prior to eye opening, we directly test several critical predictions of an LE/LI mechanism. We show that cortical networks transform uniform stimulations into diverse modular patterns exhibiting a characteristic spatial wavelength. Moreover, patterned optogenetic stimulation matching this wavelength selectively biases evoked activity patterns, "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.03.02.583133"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10925298"],"repository":["biostudies-literature"],"pubmed_title":["Self-organization of modular activity in immature cortical networks."],"pmcid":["PMC10925298"],"funding_grant_id":["R01 EY030893","F32 MH115688"],"pubmed_authors":["Smith GB","Mulholland HN","Kaschube M"],"additional_accession":[]},"is_claimable":false,"name":"Self-organization of modular activity in immature cortical networks.","description":"During development, cortical activity is organized into distributed modular patterns that are a precursor of the mature columnar functional architecture. Theoretically, such structured neural activity can emerge dynamically from local synaptic interactions through a recurrent network with effective local excitation with lateral inhibition (LE/LI) connectivity. Utilizing simultaneous widefield calcium imaging and optogenetics in juvenile ferret cortex prior to eye opening, we directly test several critical predictions of an LE/LI mechanism. We show that cortical networks transform uniform stimulations into diverse modular patterns exhibiting a characteristic spatial wavelength. Moreover, patterned optogenetic stimulation matching this wavelength selectively biases evoked activity patterns, ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-05T13:58:09.712Z","creation":"2025-04-05T13:58:09.712Z"},"accession":"S-EPMC10925298","cross_references":{"pubmed":["38464130"],"doi":["10.1101/2024.03.02.583133"]}}