{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Ferrer P"],"funding":["NICHD NIH HHS","NIEHS NIH HHS"],"pubmed_abstract":["A mechanistic role for nuclear function of testis-specific actin related proteins (ARPs) is proposed here through contributions of ARP subunit swapping in canonical chromatin regulatory complexes. This is significant to our understanding of both mechanisms controlling regulation of spermiogenesis, and the expanding functional roles of the ARPs in cell biology. Among these roles, actins and ARPs are pivotal not only in cytoskeletal regulation, but also in intranuclear chromatin organization, influencing gene regulation and nucleosome remodeling. This study focuses on two testis-specific ARPs, ACTL7A and ACTL7B, exploring their intranuclear activities and broader implications utilizing combined <i>in vivo</i>, <i>in vitro</i>, and <i>in silico</i> approaches. ACTL7A and ACTL7B, previously as"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.02.29.582797"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10925299"],"repository":["biostudies-literature"],"pubmed_title":["Novel Nuclear Roles for Testis-Specific ACTL7A and ACTL7B Supported by <i>In Vivo</i> Characterizations and AI Facilitated <i>In Silico</i> Mechanistic Modeling with Implications for Epigenetic Regulation in Spermiogenesis."],"pmcid":["PMC10925299"],"funding_grant_id":["T32 ES026568","R00 HD081204"],"pubmed_authors":["Upadhyay S","Ferrer P","Clement TM","Cai JJ"],"additional_accession":[]},"is_claimable":false,"name":"Novel Nuclear Roles for Testis-Specific ACTL7A and ACTL7B Supported by <i>In Vivo</i> Characterizations and AI Facilitated <i>In Silico</i> Mechanistic Modeling with Implications for Epigenetic Regulation in Spermiogenesis.","description":"A mechanistic role for nuclear function of testis-specific actin related proteins (ARPs) is proposed here through contributions of ARP subunit swapping in canonical chromatin regulatory complexes. This is significant to our understanding of both mechanisms controlling regulation of spermiogenesis, and the expanding functional roles of the ARPs in cell biology. Among these roles, actins and ARPs are pivotal not only in cytoskeletal regulation, but also in intranuclear chromatin organization, influencing gene regulation and nucleosome remodeling. This study focuses on two testis-specific ARPs, ACTL7A and ACTL7B, exploring their intranuclear activities and broader implications utilizing combined <i>in vivo</i>, <i>in vitro</i>, and <i>in silico</i> approaches. ACTL7A and ACTL7B, previously as","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-07-01T03:22:50.521Z","creation":"2024-11-07T11:27:11.327Z"},"accession":"S-EPMC10925299","cross_references":{"pubmed":["38464253"],"doi":["10.1101/2024.02.29.582797"]}}