{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(12)"],"submitter":["El-Hassanein AM"],"pubmed_abstract":["A novel, simple, affordable, and reliable colorimetric paper-based analytical device (PAD) was developed for the point-of-use quality testing of ethanol-based hand sanitizers, mainly against adulteration by water. The principle was based on the novel solvatochromism of methylparaben (MPB)-Fe<sup>3+</sup> complex, where water is essential for complex formation and ethanol is necessary for MPB solubility. The intensity of the formed violet color, measured at 528 nm, showed a good correlation (<i>R</i><sup>2</sup> = 0.996) with the percentage water in the reaction media over a range from 40% to 100% (0-60% ethanol), with excellent accuracy and precision as indicated by the percent recovery within 100.00% ± 2% and %RSD of <2%. A PAD was prepared by the sequential immobilization of Fe<sup>3+</sup> ions and MPB on chitosan-modified filter paper. The developed PAD was successfully applied for the quality testing of ethanol-based hand sanitizers using an established color index, where clearly distinct colors were observed as a function of the percentage ethanol (0-100%). The developed test strips could achieve on-site lab-quality results without expensive or sophisticated instruments using a few milligrams of FeCl<sub>3</sub> and MPB in addition to regular filter paper. Accordingly, it can be used as a test strip for the quality checking of ethanol-based hand sanitizers by end users."],"journal":["RSC advances"],"pagination":["8188-8194"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10925907"],"repository":["biostudies-literature"],"pubmed_title":["Simple colorimetric paper-based test strip for point-of-use quality testing of ethanol-based hand sanitizers."],"pmcid":["PMC10925907"],"pubmed_authors":["El-Hassanein AM","Mansour FR","Hammad SF","Abdella AA"],"additional_accession":[]},"is_claimable":false,"name":"Simple colorimetric paper-based test strip for point-of-use quality testing of ethanol-based hand sanitizers.","description":"A novel, simple, affordable, and reliable colorimetric paper-based analytical device (PAD) was developed for the point-of-use quality testing of ethanol-based hand sanitizers, mainly against adulteration by water. The principle was based on the novel solvatochromism of methylparaben (MPB)-Fe<sup>3+</sup> complex, where water is essential for complex formation and ethanol is necessary for MPB solubility. The intensity of the formed violet color, measured at 528 nm, showed a good correlation (<i>R</i><sup>2</sup> = 0.996) with the percentage water in the reaction media over a range from 40% to 100% (0-60% ethanol), with excellent accuracy and precision as indicated by the percent recovery within 100.00% ± 2% and %RSD of <2%. A PAD was prepared by the sequential immobilization of Fe<sup>3+</sup> ions and MPB on chitosan-modified filter paper. The developed PAD was successfully applied for the quality testing of ethanol-based hand sanitizers using an established color index, where clearly distinct colors were observed as a function of the percentage ethanol (0-100%). The developed test strips could achieve on-site lab-quality results without expensive or sophisticated instruments using a few milligrams of FeCl<sub>3</sub> and MPB in addition to regular filter paper. Accordingly, it can be used as a test strip for the quality checking of ethanol-based hand sanitizers by end users.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T21:31:06.068Z","creation":"2025-04-04T21:31:06.068Z"},"accession":"S-EPMC10925907","cross_references":{"pubmed":["38469198"],"doi":["10.1039/d3ra08110a"]}}