{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wood AC"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","Hass Avocado Board","NHLBI NIH HHS"],"pagination":["2797-2807"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10925911"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["153(10)"],"pubmed_abstract":["<h4>Background</h4>Avocado consumption is linked to better glucose homeostasis, but small associations suggest potential population heterogeneity. Metabolomic data capture the effects of food intake after digestion and metabolism, thus accounting for individual differences in these processes.<h4>Objectives</h4>To identify metabolomic biomarkers of avocado intake and to examine their associations with glycemia.<h4>Methods</h4>Baseline data from 6224 multi-ethnic older adults (62% female) included self-reported avocado intake, fasting glucose and insulin, and untargeted plasma proton nuclear magnetic resonance metabolomic features (metabolomic data were available for a randomly selected subset; N = 3438). Subsequently, incident type 2 diabetes (T2D) was assessed over an ∼18 y follow-up period. A metabolome-wide association study of avocado consumption status (consumer compared with nonconsumer) was conducted, and the relationship of these features with glycemia via cross-sectional associations with fasting insulin and glucose and longitudinal associations with incident T2D was examined.<h4>Results</h4>Three highly-correlated spectral features were associated with avocado intake at metabolome-wide significance levels (P < 5.3 ∗ 10<sup>-7</sup>) and combined into a single biomarker. We did not find evidence that these features were additionally associated with overall dietary quality, nor with any of 47 other food groups (all P > 0.001), supporting their suitability as a biomarker of avocado intake. Avocado intake showed a modest association only with lower fasting insulin (β = -0.07 <sup>+/-</sup> 0.03, P = 0.03), an association that was attenuated to nonsignificance when additionally controlling for body mass index (kg/m<sup>2</sup>). However, our biomarker of avocado intake was strongly associated with lower fasting glucose (β = -0.22 <sup>+/-</sup> 0.02, P < 2.0 ∗ 10<sup>-16</sup>), lower fasting insulin (β = -0.17 <sup>+/-</sup> 0.02, P < 2.0 ∗ 10<sup>-16</sup>), and a lower incidence of T2D (hazard ratio: 0.68; 0.63-074, P < 2.0 ∗ 10<sup>-16</sup>), even when adjusting for BMI.<h4>Conclusions</h4>Highly significant associations between glycemia and avocado-related metabolomic features, which serve as biomarkers of the physiological impact of dietary intake after digestion and absorption, compared to modest relationships between glycemia and avocado consumption, highlights the importance of considering individual differences in metabolism when considering diet-health relationships."],"journal":["The Journal of nutrition"],"pubmed_title":["Associations between Metabolomic Biomarkers of Avocado Intake and Glycemia in the Multi-Ethnic Study of Atherosclerosis."],"pmcid":["PMC10925911"],"funding_grant_id":["UL1 TR000040","UL1 TR001079","UL1 TR001420","UL1 TR001881","N01 HC095166","N01 HC095165","K23 DK119404","N01 HC095168","R01 DK109588","N01 HC095167","N01 HC095159","N01 HC095169","R01 HL133932","N01 HC095160","N01 HC095162","N01 HC095161","N01 HC095164","N01 HC095163","P30 DK063491","R01 HL105756"],"pubmed_authors":["Rotter JI","Greenland P","Wood AC","Elliott P","Herrington DM","Ebbels T","Tzoulaki I","Gadgil MD","Senn MK","Graca G","Goodarzi MO","Allison MA","Tracy RP","Mi MY"],"additional_accession":[]},"is_claimable":false,"name":"Associations between Metabolomic Biomarkers of Avocado Intake and Glycemia in the Multi-Ethnic Study of Atherosclerosis.","description":"<h4>Background</h4>Avocado consumption is linked to better glucose homeostasis, but small associations suggest potential population heterogeneity. Metabolomic data capture the effects of food intake after digestion and metabolism, thus accounting for individual differences in these processes.<h4>Objectives</h4>To identify metabolomic biomarkers of avocado intake and to examine their associations with glycemia.<h4>Methods</h4>Baseline data from 6224 multi-ethnic older adults (62% female) included self-reported avocado intake, fasting glucose and insulin, and untargeted plasma proton nuclear magnetic resonance metabolomic features (metabolomic data were available for a randomly selected subset; N = 3438). Subsequently, incident type 2 diabetes (T2D) was assessed over an ∼18 y follow-up period. A metabolome-wide association study of avocado consumption status (consumer compared with nonconsumer) was conducted, and the relationship of these features with glycemia via cross-sectional associations with fasting insulin and glucose and longitudinal associations with incident T2D was examined.<h4>Results</h4>Three highly-correlated spectral features were associated with avocado intake at metabolome-wide significance levels (P < 5.3 ∗ 10<sup>-7</sup>) and combined into a single biomarker. We did not find evidence that these features were additionally associated with overall dietary quality, nor with any of 47 other food groups (all P > 0.001), supporting their suitability as a biomarker of avocado intake. Avocado intake showed a modest association only with lower fasting insulin (β = -0.07 <sup>+/-</sup> 0.03, P = 0.03), an association that was attenuated to nonsignificance when additionally controlling for body mass index (kg/m<sup>2</sup>). However, our biomarker of avocado intake was strongly associated with lower fasting glucose (β = -0.22 <sup>+/-</sup> 0.02, P < 2.0 ∗ 10<sup>-16</sup>), lower fasting insulin (β = -0.17 <sup>+/-</sup> 0.02, P < 2.0 ∗ 10<sup>-16</sup>), and a lower incidence of T2D (hazard ratio: 0.68; 0.63-074, P < 2.0 ∗ 10<sup>-16</sup>), even when adjusting for BMI.<h4>Conclusions</h4>Highly significant associations between glycemia and avocado-related metabolomic features, which serve as biomarkers of the physiological impact of dietary intake after digestion and absorption, compared to modest relationships between glycemia and avocado consumption, highlights the importance of considering individual differences in metabolism when considering diet-health relationships.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-06-27T03:13:14.481Z","creation":"2025-04-06T01:45:26.961Z"},"accession":"S-EPMC10925911","cross_references":{"pubmed":["37562669"],"doi":["10.1016/j.tjnut.2023.07.013"]}}