{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zammit AR"],"funding":["NIA NIH HHS","Illinois Department of Public Health","National Institutes of Health","NIH HHS"],"pagination":["390-398"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10926217"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72(2)"],"pubmed_abstract":["<h4>Background</h4>Many studies indicate that smaller life space is related to worse cognitive and motor function. It is plausible that cognitive and motor function also predict life space constriction, thus long-term, prospective studies are needed of cognitive and motor function as predictors of life space.<h4>Methods</h4>A total of 1246 participants of the Rush Memory and Aging Project, who reported initial maximal life space and at least one follow-up assessment were included in this prospective study, with up to 19 years follow-up. The outcome of interest was the Modified version of the Life Space Questionnaire; which we categorized into large (beyond community), medium (neighborhood/community), and small (home/yard) life space. Participants also had detailed composite measures of global cognition and motor function as predictors and available at the first life space assessment. Life space transitions over one-year periods were modeled using multistate Markov modeling, including confounders and both predictors simultaneously.<h4>Results</h4>Better cognitive and motor function were broadly associated with lower odds of life space constriction (Cognitive: Large ➔ medium: OR = 0.91, 95% CI 0.83-1.00; Large ➔ small: OR = 0.85, 95% CI 0.74-0.97; Medium ➔ small: OR = 1.01, 95% CI 0.82-1.22. Motor: large ➔ medium: OR = 0.76, 95% CI 0.69-0.83; large ➔ small: OR = 0.58, 95% CI 0.51-0.67; medium ➔ small: OR = 0.71, 95% CI = 0.57-0.87).<h4>Conclusions</h4>Combined with previous literature that life space predicts function, these results support the notion of complex inter-relations of cognitive function, motor function, and life space."],"journal":["Journal of the American Geriatrics Society"],"pubmed_title":["A prospective study of the association of cognitive and motor function with odds of life space constriction in older adults."],"pmcid":["PMC10926217"],"funding_grant_id":["R01 AG015819","R01 AG079133","K01AG054700","R01 AG017917","R01AG17917","R01AG15819","K01 AG054700"],"pubmed_authors":["Yu L","Bennett DA","Zammit AR","Lange-Maia BS","Buchman AS","Grodstein F"],"additional_accession":[]},"is_claimable":false,"name":"A prospective study of the association of cognitive and motor function with odds of life space constriction in older adults.","description":"<h4>Background</h4>Many studies indicate that smaller life space is related to worse cognitive and motor function. It is plausible that cognitive and motor function also predict life space constriction, thus long-term, prospective studies are needed of cognitive and motor function as predictors of life space.<h4>Methods</h4>A total of 1246 participants of the Rush Memory and Aging Project, who reported initial maximal life space and at least one follow-up assessment were included in this prospective study, with up to 19 years follow-up. The outcome of interest was the Modified version of the Life Space Questionnaire; which we categorized into large (beyond community), medium (neighborhood/community), and small (home/yard) life space. Participants also had detailed composite measures of global cognition and motor function as predictors and available at the first life space assessment. Life space transitions over one-year periods were modeled using multistate Markov modeling, including confounders and both predictors simultaneously.<h4>Results</h4>Better cognitive and motor function were broadly associated with lower odds of life space constriction (Cognitive: Large ➔ medium: OR = 0.91, 95% CI 0.83-1.00; Large ➔ small: OR = 0.85, 95% CI 0.74-0.97; Medium ➔ small: OR = 1.01, 95% CI 0.82-1.22. Motor: large ➔ medium: OR = 0.76, 95% CI 0.69-0.83; large ➔ small: OR = 0.58, 95% CI 0.51-0.67; medium ➔ small: OR = 0.71, 95% CI = 0.57-0.87).<h4>Conclusions</h4>Combined with previous literature that life space predicts function, these results support the notion of complex inter-relations of cognitive function, motor function, and life space.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-21T23:50:31.437Z","creation":"2025-04-05T19:18:28.15Z"},"accession":"S-EPMC10926217","cross_references":{"pubmed":["37905593"],"doi":["10.1111/jgs.18640"]}}