biostudies-literatureVerstraeten RNHLBI NIH HHSe029637https://www.ebi.ac.uk/biostudies/studies/S-EPMC10926821biostudies-literatureUnknown13(2)<h4>Background</h4>HIV and antiretroviral therapy (ART) have been associated with increased cardiovascular disease (CVD) risk in high-income countries. The authors studied the longitudinal association between HIV and ART and nonlaboratory Framingham Risk Score (FRS) in a middle-income country.<h4>Methods and results</h4>This longitudinal analysis of the NCS (Ndlovu Cohort Study), South Africa used baseline to 36-month follow-up data. Demographics, HIV, ART status, and cardiometabolic measures were obtained. FRS was used as a CVD risk measure. Through linear mixed models, FRS trends over time and the association with HIV were studied. Analysis included 1136 participants, with 609 (54%) having HIV, and 495 (81%) taking ART. At baseline, 9.8% of participants had a high FRS. People living withJournal of the American Heart AssociationNo Evidence for an Association of HIV and Antiviral Treatment With Changes in Framingham Cardiovascular Risk Score in the Ndlovu Cohort Study.PMC10926821UG3 HL156388Barth REGrobbee DECoutinho RAVenter FBoateng DKlipstein-Grobusch KScheuermaier KDeville WVerstraeten RTempelman HVos-Seda AGfalseNo Evidence for an Association of HIV and Antiviral Treatment With Changes in Framingham Cardiovascular Risk Score in the Ndlovu Cohort Study.<h4>Background</h4>HIV and antiretroviral therapy (ART) have been associated with increased cardiovascular disease (CVD) risk in high-income countries. The authors studied the longitudinal association between HIV and ART and nonlaboratory Framingham Risk Score (FRS) in a middle-income country.<h4>Methods and results</h4>This longitudinal analysis of the NCS (Ndlovu Cohort Study), South Africa used baseline to 36-month follow-up data. Demographics, HIV, ART status, and cardiometabolic measures were obtained. FRS was used as a CVD risk measure. Through linear mixed models, FRS trends over time and the association with HIV were studied. Analysis included 1136 participants, with 609 (54%) having HIV, and 495 (81%) taking ART. At baseline, 9.8% of participants had a high FRS. People living with2024-01-01T00:00:00Z2024 Jan2025-04-22T16:18:02.396Z2024-12-04T09:27:17.376ZS-EPMC109268213821431910.1161/JAHA.123.029637