{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sebastiao YV"],"funding":["NIDDK NIH HHS"],"pagination":["111-118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10928559"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(1)"],"pubmed_abstract":["<h4>Background</h4>Obstructive uropathy (OU) is a leading cause of pediatric kidney injury. Accurate prediction of kidney disease progression may improve clinical outcomes. We aimed to examine discrimination and accuracy of a validated kidney failure risk equation (KFRE), previously developed in adults, in children with OU.<h4>Methods</h4>We identified 118 children with OU and an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m<sup>2</sup> in the Chronic Kidney Disease in Children study, a national, longitudinal, observational cohort. Each patient's 5-year risk of kidney failure was estimated using baseline data and published parameters for the 4- and 8-variable KFREs. Discriminative ability of the KFRE was estimated using the C statistic for time-to-event analysis. Sensitivity and specificity were evaluated across varying risk thresholds.<h4>Results</h4>Among the 118 children, 100 (85%) were boys, with median baseline age of 10 years (interquartile range, 6-14). Median eGFR was 42 mL/min/1.73m <sup>2</sup> (32-53), with a median follow-up duration of 4.5 years (2.7-7.2); 23 patients (19.5%) developed kidney failure within 5 years. The 4-variable KFRE discriminated kidney failure risk with a C statistic of 0.75 (95% CI, 0.68-0.82). A 4-variable risk threshold of ≥ 30% yielded 82.6% sensitivity and 75.0% specificity. Results were similar using the 8-variable KFRE.<h4>Conclusions</h4>In children with OU, the KFRE discriminated the 5-year risk of kidney failure at C statistic values lower than previously published in adults but comparable with suboptimal values reported in the overall CKiD population. The 8-variable equation did not improve model discrimination or accuracy, suggesting the need for continued research into additional, disease-specific markers."],"journal":["Pediatric nephrology (Berlin, Germany)"],"pubmed_title":["Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy."],"pmcid":["PMC10928559"],"funding_grant_id":["U01 DK066174","R01 DK125469","U01 DK066143","U24 DK082194","U24 DK066116"],"pubmed_authors":["Becknell B","Ching CB","McLeod DJ","Sebastiao YV","Cooper JN"],"additional_accession":[]},"is_claimable":false,"name":"Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy.","description":"<h4>Background</h4>Obstructive uropathy (OU) is a leading cause of pediatric kidney injury. Accurate prediction of kidney disease progression may improve clinical outcomes. We aimed to examine discrimination and accuracy of a validated kidney failure risk equation (KFRE), previously developed in adults, in children with OU.<h4>Methods</h4>We identified 118 children with OU and an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m<sup>2</sup> in the Chronic Kidney Disease in Children study, a national, longitudinal, observational cohort. Each patient's 5-year risk of kidney failure was estimated using baseline data and published parameters for the 4- and 8-variable KFREs. Discriminative ability of the KFRE was estimated using the C statistic for time-to-event analysis. Sensitivity and specificity were evaluated across varying risk thresholds.<h4>Results</h4>Among the 118 children, 100 (85%) were boys, with median baseline age of 10 years (interquartile range, 6-14). Median eGFR was 42 mL/min/1.73m <sup>2</sup> (32-53), with a median follow-up duration of 4.5 years (2.7-7.2); 23 patients (19.5%) developed kidney failure within 5 years. The 4-variable KFRE discriminated kidney failure risk with a C statistic of 0.75 (95% CI, 0.68-0.82). A 4-variable risk threshold of ≥ 30% yielded 82.6% sensitivity and 75.0% specificity. Results were similar using the 8-variable KFRE.<h4>Conclusions</h4>In children with OU, the KFRE discriminated the 5-year risk of kidney failure at C statistic values lower than previously published in adults but comparable with suboptimal values reported in the overall CKiD population. The 8-variable equation did not improve model discrimination or accuracy, suggesting the need for continued research into additional, disease-specific markers.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2024-11-07T11:34:20.585Z","creation":"2024-11-07T11:34:20.585Z"},"accession":"S-EPMC10928559","cross_references":{"pubmed":["32583045"],"doi":["10.1007/s00467-020-04661-w"]}}