{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Co VA"],"funding":["HKU Internal grant","Research Council of Finland","UoP Start-up Fund"],"pagination":["863-877"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10928902"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(3)"],"pubmed_abstract":["Colon cancer is among the most lethal and prevalent malignant tumors in the world, and the lack of effective therapies highlights the need for novel therapeutic approaches. Schisandrin B (Sch B), a lignan extracted from the fruit of<i>Schisandra chinensis</i>, has been reported for its anticancer properties. However, to date, no studies have been done to characterize the exact molecular mechanisms underlying the antitumorigenic effects of Sch B in colon cancer. This study aimed to explore the antitumorigenic effects of Sch B in colon cancer and to understand the underlying therapeutic mechanism. A comprehensive analysis of the molecular mechanism underlying the antitumorigenic effects of Sch B on human colon cancer cells was performed using a combination of Raman spectroscopy, RNA-seq, computational docking, and molecular biological experiments. The <i>in vivo</i> efficacy was evaluated by a mouse xenograft model. Sch B reduced cell proliferation and triggered apoptosis in human colon cancer cell lines. Raman spectroscopy, computational, RNA-seq, and molecular and cellular studies revealed that Sch B activated unfolded protein responses by interacting with CHOP and upregulating CHOP, which thereby induced apoptosis. CHOP knockdown alleviated the Sch B-induced reduction in cell viability and apoptosis. Sch B reduced colon tumor growth <i>in vivo</i>. Our findings demonstrated that Sch B induced apoptosis and inhibited cell proliferation and tumor growth <i>in vitro</i> and <i>in vivo</i>. These results provided an essential background for clinical trials examining the effects of Sch B in patients with colon cancer."],"journal":["ACS pharmacology & translational science"],"pubmed_title":["Schisandrin B Suppresses Colon Cancer Growth by Inducing Cell Cycle Arrest and Apoptosis: Molecular Mechanism and Therapeutic Potential."],"pmcid":["PMC10928902"],"funding_grant_id":["355462","44239"],"pubmed_authors":["Liu Y","Cox PA","Dey P","Agbodjan-Dossou R","Twum B","Sabzichi M","El-Nezami H","Joseph S","Co VA","Wan MLY","Draheim R"],"additional_accession":[]},"is_claimable":false,"name":"Schisandrin B Suppresses Colon Cancer Growth by Inducing Cell Cycle Arrest and Apoptosis: Molecular Mechanism and Therapeutic Potential.","description":"Colon cancer is among the most lethal and prevalent malignant tumors in the world, and the lack of effective therapies highlights the need for novel therapeutic approaches. Schisandrin B (Sch B), a lignan extracted from the fruit of<i>Schisandra chinensis</i>, has been reported for its anticancer properties. However, to date, no studies have been done to characterize the exact molecular mechanisms underlying the antitumorigenic effects of Sch B in colon cancer. This study aimed to explore the antitumorigenic effects of Sch B in colon cancer and to understand the underlying therapeutic mechanism. A comprehensive analysis of the molecular mechanism underlying the antitumorigenic effects of Sch B on human colon cancer cells was performed using a combination of Raman spectroscopy, RNA-seq, computational docking, and molecular biological experiments. The <i>in vivo</i> efficacy was evaluated by a mouse xenograft model. Sch B reduced cell proliferation and triggered apoptosis in human colon cancer cell lines. Raman spectroscopy, computational, RNA-seq, and molecular and cellular studies revealed that Sch B activated unfolded protein responses by interacting with CHOP and upregulating CHOP, which thereby induced apoptosis. CHOP knockdown alleviated the Sch B-induced reduction in cell viability and apoptosis. Sch B reduced colon tumor growth <i>in vivo</i>. Our findings demonstrated that Sch B induced apoptosis and inhibited cell proliferation and tumor growth <i>in vitro</i> and <i>in vivo</i>. These results provided an essential background for clinical trials examining the effects of Sch B in patients with colon cancer.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-01T13:01:12.296Z","creation":"2025-04-04T13:11:22.945Z"},"accession":"S-EPMC10928902","cross_references":{"pubmed":["38481680"],"doi":["10.1021/acsptsci.4c00009"]}}