{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Conner SJ"],"funding":["NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","National Cancer Institute","Breast Cancer Alliance","NCI NIH HHS"],"pagination":["43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10929179"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["<h4>Background</h4>Metastasis is the leading cause of death in breast cancer patients. For metastasis to occur, tumor cells must invade locally, intravasate, and colonize distant tissues and organs, all steps that require tumor cell migration. The majority of studies on invasion and metastasis rely on human breast cancer cell lines. While it is known that these cells have different properties and abilities for growth and metastasis, the in vitro morphological, proliferative, migratory, and invasive behavior of these cell lines and their correlation to in vivo behavior is poorly understood. Thus, we sought to classify each cell line as poorly or highly metastatic by characterizing tumor growth and metastasis in a murine model of six commonly used human triple-negative breast cancer xenograf"],"journal":["Breast cancer research : BCR"],"pubmed_title":["Cell morphology best predicts tumorigenicity and metastasis in vivo across multiple TNBC cell lines of different metastatic potential."],"pmcid":["PMC10929179"],"funding_grant_id":["R00-CA207866","T32 DK124170","R00 CA207866","1T32DK124170-01","R01CA255742","DP2CA271387"],"pubmed_authors":["Fatherree JP","McGinn RA","Guarin JR","Bloomer H","Salhany K","Kelley C","Payne SL","Srinivasan D","Oudin MJ","Conner SJ","Henrich E","Yui A","Le TT","Zhang C","Borges H","Parker SR"],"additional_accession":[]},"is_claimable":false,"name":"Cell morphology best predicts tumorigenicity and metastasis in vivo across multiple TNBC cell lines of different metastatic potential.","description":"<h4>Background</h4>Metastasis is the leading cause of death in breast cancer patients. For metastasis to occur, tumor cells must invade locally, intravasate, and colonize distant tissues and organs, all steps that require tumor cell migration. The majority of studies on invasion and metastasis rely on human breast cancer cell lines. While it is known that these cells have different properties and abilities for growth and metastasis, the in vitro morphological, proliferative, migratory, and invasive behavior of these cell lines and their correlation to in vivo behavior is poorly understood. Thus, we sought to classify each cell line as poorly or highly metastatic by characterizing tumor growth and metastasis in a murine model of six commonly used human triple-negative breast cancer xenograf","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-22T13:03:48.628Z","creation":"2025-04-06T00:29:50.633Z"},"accession":"S-EPMC10929179","cross_references":{"pubmed":["38468326"],"doi":["10.1186/s13058-024-01796-8"]}}