biostudies-literatureWang Jthe National Natural Science Foundation of China1602-1610https://www.ebi.ac.uk/biostudies/studies/S-EPMC10929888biostudies-literatureUnknown48(10)Chronic urticaria is very common in clinic, but its pathogenesis is not fully elucidated. Most patients can't find the exact cause, resulting in misdiagnosis or delayed treatment. Previous studies have found that mast cell activation is the central link in the pathogenesis of chronic urticaria. Genetics, autoimmune, coagulation disorders, and infection may also be involved in the pathophysiological process of chronic urticaria. With the deepening of research, more immune and non-immune mechanisms have been gradually revealed in the pathogenesis of chronic urticaria, such as the interaction of immune cells in the microenvironment of urticaria, intestinal flora and metabolism, neuroimmunity, environmental factors and hormones. Clarifying the pathogenesis of chronic urticaria will help to find more treatment targets and provide more diversified ideas for clinical diagnosis and treatment.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesResearch progress in the pathogenesis of chronic urticaria.PMC1092988882173424 and 81974476Li JWang JfalseResearch progress in the pathogenesis of chronic urticaria.Chronic urticaria is very common in clinic, but its pathogenesis is not fully elucidated. Most patients can't find the exact cause, resulting in misdiagnosis or delayed treatment. Previous studies have found that mast cell activation is the central link in the pathogenesis of chronic urticaria. Genetics, autoimmune, coagulation disorders, and infection may also be involved in the pathophysiological process of chronic urticaria. With the deepening of research, more immune and non-immune mechanisms have been gradually revealed in the pathogenesis of chronic urticaria, such as the interaction of immune cells in the microenvironment of urticaria, intestinal flora and metabolism, neuroimmunity, environmental factors and hormones. Clarifying the pathogenesis of chronic urticaria will help to find more treatment targets and provide more diversified ideas for clinical diagnosis and treatment.2023-01-01T00:00:00Z2023 Oct2025-04-19T22:05:28.587Z2025-04-19T22:05:28.587ZS-EPMC109298883843288910.11817/j.issn.1672-7347.2023.230037