{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang X"],"funding":["Hainan Province Science and Technology Special Fund","Chinese Academy of Tropical Agricultural Sciences for Science and Technology Innovation Team of National Tropical Agricultural Science Center","Central Public-interest Scientific Institution Basal Research Fund","Sanya Yazhou Bay Science and Technology City"],"pagination":["701"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10930650"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(5)"],"pubmed_abstract":["This study investigated the immunoprotective effects of the extract of <i>Vanilla planifolia Andrew</i> (EVPA) on cyclophosphamide (Cy)-induced immunosuppression in mice. The results show that EVPA administration significantly alleviated the immune damage induced by Cy, as evidenced by an improved body weight, organ index, and colonic injury. A further analysis of microbial diversity revealed that the EVPA primarily increased the abundance of the beneficial bacteria <i>Verrucomicrobiota</i>, <i>Lactobacillaceae</i>, and <i>Lactobacillus</i> while decreasing <i>Akkermansiaceae</i>, <i>Akkermansia</i>, <i>Romboutsia</i>, and <i>Lactococcus</i>, thereby ameliorating the microbial dysbiosis caused by Cy. A metabolomic analysis revealed significant alterations in the microbial metabolite levels"],"journal":["Foods (Basel, Switzerland)"],"pubmed_title":["Microbiome-Metabolomic Analysis Revealed the Immunoprotective Effects of the Extract of <i>Vanilla planifolia Andrew</i> (EVPA) on Immunosuppressed Mice."],"pmcid":["PMC10930650"],"funding_grant_id":["ZDYF2022XDNY268","CATASCXTD202304","1630142022008","SCKJ-JYRC-2022-25"],"pubmed_authors":["Li Y","Li C","Zhao Q","Gu F","Zhang X","Zhu K","Xu F","Chu Z"],"additional_accession":[]},"is_claimable":false,"name":"Microbiome-Metabolomic Analysis Revealed the Immunoprotective Effects of the Extract of <i>Vanilla planifolia Andrew</i> (EVPA) on Immunosuppressed Mice.","description":"This study investigated the immunoprotective effects of the extract of <i>Vanilla planifolia Andrew</i> (EVPA) on cyclophosphamide (Cy)-induced immunosuppression in mice. The results show that EVPA administration significantly alleviated the immune damage induced by Cy, as evidenced by an improved body weight, organ index, and colonic injury. A further analysis of microbial diversity revealed that the EVPA primarily increased the abundance of the beneficial bacteria <i>Verrucomicrobiota</i>, <i>Lactobacillaceae</i>, and <i>Lactobacillus</i> while decreasing <i>Akkermansiaceae</i>, <i>Akkermansia</i>, <i>Romboutsia</i>, and <i>Lactococcus</i>, thereby ameliorating the microbial dysbiosis caused by Cy. A metabolomic analysis revealed significant alterations in the microbial metabolite levels","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-07-09T10:45:27.293Z","creation":"2026-07-09T10:26:21.002Z"},"accession":"S-EPMC10930650","cross_references":{"pubmed":["38472814"],"doi":["10.3390/foods13050701"]}}