{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garrido P"],"funding":["Fundacion Rioja Salud","Fundación Rioja Salud"],"pagination":["960"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10930957"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(5)"],"pubmed_abstract":["Non-coding RNAs provide new opportunities to identify biomarkers that properly classify cancer patients. Here, we study the biomarker status of the mitochondrial long non-coding RNAs, MDL1 and MDL1AS. Expression of these genes was studied in public transcriptomic databases. In addition, a cohort of 69 locally advanced rectal cancer (LARC) patients with a follow-up of more than 5 years was used to determine the prognostic value of these markers. Furthermore, cell lines of colorectal (HCT116) and breast (MDA-MB-231) carcinoma were employed to study the effects of downregulating MDL1AS in vitro. Expression of MDL1AS (but not MDL1) was significantly different in tumor cells than in the surrounding tissue in a tumor-type-specific context. Both MDL1 and MDL1AS were accurate biomarkers for the 5-"],"journal":["Cancers"],"pubmed_title":["Expression of Mitochondrial Long Non-Coding RNAs, MDL1 and MDL1AS, Are Good Prognostic and/or Diagnostic Biomarkers for Several Cancers, Including Colorectal Cancer."],"pmcid":["PMC10930957"],"funding_grant_id":["Onco-1"],"pubmed_authors":["Casas-Benito A","Narro-Iniguez J","Martin-Carnicero A","Zozaya E","Rubio-Mediavilla S","Garrido P","Martinez A","Larrayoz IM"],"additional_accession":[]},"is_claimable":false,"name":"Expression of Mitochondrial Long Non-Coding RNAs, MDL1 and MDL1AS, Are Good Prognostic and/or Diagnostic Biomarkers for Several Cancers, Including Colorectal Cancer.","description":"Non-coding RNAs provide new opportunities to identify biomarkers that properly classify cancer patients. Here, we study the biomarker status of the mitochondrial long non-coding RNAs, MDL1 and MDL1AS. Expression of these genes was studied in public transcriptomic databases. In addition, a cohort of 69 locally advanced rectal cancer (LARC) patients with a follow-up of more than 5 years was used to determine the prognostic value of these markers. Furthermore, cell lines of colorectal (HCT116) and breast (MDA-MB-231) carcinoma were employed to study the effects of downregulating MDL1AS in vitro. Expression of MDL1AS (but not MDL1) was significantly different in tumor cells than in the surrounding tissue in a tumor-type-specific context. Both MDL1 and MDL1AS were accurate biomarkers for the 5-","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-19T05:50:07.355Z","creation":"2025-04-19T05:50:07.355Z"},"accession":"S-EPMC10930957","cross_references":{"pubmed":["38473321"],"doi":["10.3390/cancers16050960"]}}