{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fang F"],"funding":["NIDA NIH HHS","NIEHS NIH HHS","Jonsson Comprehensive Cancer Center","NCI NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["1579-1586"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10932807"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["154(9)"],"pubmed_abstract":["Fine particulate matter (PM<sub>2.5</sub> ) contains carcinogens similar to those generated by tobacco smoking, which may increase the risks of developing smoking-related cancers, such as upper aerodigestive track (UADT) cancers, for both smokers and never-smokers. Therefore, it is imperative to understand the relation between ambient PM<sub>2.5</sub> exposure and risk of UADT cancers. A population-based case-control study involving 565 incident UADT cancer cases and 983 controls was conducted in Los Angeles County from 1999 to 2004. The average residential PM<sub>2.5</sub> concentration 1 year before the diagnosis date for cases and the reference date for controls was assessed using a chemical transport model. The association between ambient PM<sub>2.5</sub> and the UADT cancers was estimated by unconditional logistic regression, adjusting for confounders at the individual and block-group level. Stratified analyses were conducted by sex, tobacco smoking status and UADT subsites. We also assessed the interaction between PM<sub>2.5</sub> and tobacco smoking on UADT cancers. PM<sub>2.5</sub> concentrations were associated with an elevated odds of UADT cancers (adjusted odds ratio = 1.21 per interquartile range [4.5 μg/m<sup>3</sup> ] increase; 95% confidence interval: 1.02, 1.44). The association between PM<sub>2.5</sub> and UADT cancers was similar across UADT subsites, sex and tobacco smoking status. The interaction between PM<sub>2.5</sub> and tobacco smoking on UADT cancers was approximately additive on the odds scale. The effect estimate for PM<sub>2.5</sub> and UADT cancers was similar among never smokers. Our findings support the hypothesis that exposure to PM<sub>2.5</sub> increases the risk of UADT cancers. Improvements in air quality may reduce the risk of UADT cancers."],"journal":["International journal of cancer"],"pubmed_title":["Association between ambient exposure to PM&lt;sub&gt;2.5&lt;/sub&gt; and upper aerodigestive tract cancer in Los Angeles."],"pmcid":["PMC10932807"],"funding_grant_id":["CA90833","ES06718","DA11386","T32 CA009142","CA077954","U01 CA096134","R21 ES011667","R03 CA077954","R01 CA090833","R01 DA011386","ES011667","CA96134","CA009142"],"pubmed_authors":["Morgenstern H","Ritz B","Zhu Y","Zhang ZF","Fang F","Tashkin DP","Rao J"],"additional_accession":[]},"is_claimable":false,"name":"Association between ambient exposure to PM&lt;sub&gt;2.5&lt;/sub&gt; and upper aerodigestive tract cancer in Los Angeles.","description":"Fine particulate matter (PM<sub>2.5</sub> ) contains carcinogens similar to those generated by tobacco smoking, which may increase the risks of developing smoking-related cancers, such as upper aerodigestive track (UADT) cancers, for both smokers and never-smokers. Therefore, it is imperative to understand the relation between ambient PM<sub>2.5</sub> exposure and risk of UADT cancers. A population-based case-control study involving 565 incident UADT cancer cases and 983 controls was conducted in Los Angeles County from 1999 to 2004. The average residential PM<sub>2.5</sub> concentration 1 year before the diagnosis date for cases and the reference date for controls was assessed using a chemical transport model. The association between ambient PM<sub>2.5</sub> and the UADT cancers was estimated by unconditional logistic regression, adjusting for confounders at the individual and block-group level. Stratified analyses were conducted by sex, tobacco smoking status and UADT subsites. We also assessed the interaction between PM<sub>2.5</sub> and tobacco smoking on UADT cancers. PM<sub>2.5</sub> concentrations were associated with an elevated odds of UADT cancers (adjusted odds ratio = 1.21 per interquartile range [4.5 μg/m<sup>3</sup> ] increase; 95% confidence interval: 1.02, 1.44). The association between PM<sub>2.5</sub> and UADT cancers was similar across UADT subsites, sex and tobacco smoking status. The interaction between PM<sub>2.5</sub> and tobacco smoking on UADT cancers was approximately additive on the odds scale. The effect estimate for PM<sub>2.5</sub> and UADT cancers was similar among never smokers. Our findings support the hypothesis that exposure to PM<sub>2.5</sub> increases the risk of UADT cancers. Improvements in air quality may reduce the risk of UADT cancers.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2025-06-27T03:05:32.069Z","creation":"2025-06-27T03:05:32.069Z"},"accession":"S-EPMC10932807","cross_references":{"pubmed":["38180239"],"doi":["10.1002/ijc.34835"]}}