{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Diaz Soria CL"],"funding":["Medical Research Council","Wellcome Trust","UK Research and Innovation"],"pagination":["5974"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10933418"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Schistosomiasis is a major Neglected Tropical Disease, caused by the infection with blood flukes in the genus Schistosoma. To complete the life cycle, the parasite undergoes asexual and sexual reproduction within an intermediate snail host and a definitive mammalian host, respectively. The intra-molluscan phase provides a critical amplification step that ensures a successful transmission. However, the cellular and molecular mechanisms underlying the development of the intra-molluscan stages remain poorly understood. Here, single cell suspensions from S. mansoni mother sporocysts were produced and sequenced using the droplet-based 10X Genomics Chromium platform. Six cell clusters comprising two tegument, muscle, neuron, parenchyma and stem/germinal cell clusters were identified and validate"],"journal":["Scientific reports"],"pubmed_title":["Single-cell transcriptomics of the human parasite Schistosoma mansoni first intra-molluscan stage reveals tentative tegumental and stem-cell regulators."],"pmcid":["PMC10933418"],"funding_grant_id":["107475/Z/15/Z","206194","MR/W013568/1"],"pubmed_authors":["Thompson S","Berriman M","Rinaldi G","Lu Z","Rawlinson KA","Hall C","Attenborough T","Andrews TGR","Diaz Soria CL","Fontenla S","Graham J"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell transcriptomics of the human parasite Schistosoma mansoni first intra-molluscan stage reveals tentative tegumental and stem-cell regulators.","description":"Schistosomiasis is a major Neglected Tropical Disease, caused by the infection with blood flukes in the genus Schistosoma. To complete the life cycle, the parasite undergoes asexual and sexual reproduction within an intermediate snail host and a definitive mammalian host, respectively. The intra-molluscan phase provides a critical amplification step that ensures a successful transmission. However, the cellular and molecular mechanisms underlying the development of the intra-molluscan stages remain poorly understood. Here, single cell suspensions from S. mansoni mother sporocysts were produced and sequenced using the droplet-based 10X Genomics Chromium platform. Six cell clusters comprising two tegument, muscle, neuron, parenchyma and stem/germinal cell clusters were identified and validate","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-04-29T14:09:47.229Z","creation":"2025-02-19T04:41:53.545Z"},"accession":"S-EPMC10933418","cross_references":{"pubmed":["38472267"],"doi":["10.1038/s41598-024-55790-3"]}}