{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tang JJ"],"funding":["Science and Technology Program of Yong Zhou","Science and Technology Innovation Program of Hunan Province"],"pagination":["997"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10934161"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(5)"],"pubmed_abstract":["The incorporation of amide groups into biologically active molecules has been proven to be an efficient strategy for drug design and discovery. In this study, we present a simple and practical method for the synthesis of amide-containing quinazolin-4(3<i>H</i>)-ones under transition-metal-free conditions. This is achieved through a carbamoyl-radical-triggered cascade cyclization of N3-alkenyl-tethered quinazolinones. Notably, the carbamoyl radical is generated in situ from the oxidative decarboxylative process of oxamic acids in the presence of (NH<sub>4</sub>)<sub>2</sub>S<sub>2</sub>O<sub>8</sub>."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Persulfate-Promoted Carbamoylation/Cyclization of Alkenes: Synthesis of Amide-Containing Quinazolinones."],"pmcid":["PMC10934161"],"funding_grant_id":["2022RC1119","2021-YZKJZD-002"],"pubmed_authors":["Zhao MY","Tang JJ","Yang LH","Xie LY","Lin YJ"],"additional_accession":[]},"is_claimable":false,"name":"Persulfate-Promoted Carbamoylation/Cyclization of Alkenes: Synthesis of Amide-Containing Quinazolinones.","description":"The incorporation of amide groups into biologically active molecules has been proven to be an efficient strategy for drug design and discovery. In this study, we present a simple and practical method for the synthesis of amide-containing quinazolin-4(3<i>H</i>)-ones under transition-metal-free conditions. This is achieved through a carbamoyl-radical-triggered cascade cyclization of N3-alkenyl-tethered quinazolinones. Notably, the carbamoyl radical is generated in situ from the oxidative decarboxylative process of oxamic acids in the presence of (NH<sub>4</sub>)<sub>2</sub>S<sub>2</sub>O<sub>8</sub>.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-26T14:25:10.475Z","creation":"2025-04-06T14:31:53.601Z"},"accession":"S-EPMC10934161","cross_references":{"pubmed":["38474508"],"doi":["10.3390/molecules29050997"]}}