biostudies-literatureTang JJScience and Technology Program of Yong ZhouScience and Technology Innovation Program of Hunan Province997https://www.ebi.ac.uk/biostudies/studies/S-EPMC10934161biostudies-literatureUnknown29(5)The incorporation of amide groups into biologically active molecules has been proven to be an efficient strategy for drug design and discovery. In this study, we present a simple and practical method for the synthesis of amide-containing quinazolin-4(3<i>H</i>)-ones under transition-metal-free conditions. This is achieved through a carbamoyl-radical-triggered cascade cyclization of N3-alkenyl-tethered quinazolinones. Notably, the carbamoyl radical is generated in situ from the oxidative decarboxylative process of oxamic acids in the presence of (NH₄)₂S₂O₈.Molecules (Basel, Switzerland)Persulfate-Promoted Carbamoylation/Cyclization of Alkenes: Synthesis of Amide-Containing Quinazolinones.PMC109341612022RC11192021-YZKJZD-002Zhao MYTang JJYang LHXie LYLin YJfalsePersulfate-Promoted Carbamoylation/Cyclization of Alkenes: Synthesis of Amide-Containing Quinazolinones.The incorporation of amide groups into biologically active molecules has been proven to be an efficient strategy for drug design and discovery. In this study, we present a simple and practical method for the synthesis of amide-containing quinazolin-4(3<i>H</i>)-ones under transition-metal-free conditions. This is achieved through a carbamoyl-radical-triggered cascade cyclization of N3-alkenyl-tethered quinazolinones. Notably, the carbamoyl radical is generated in situ from the oxidative decarboxylative process of oxamic acids in the presence of (NH₄)₂S₂O₈.2024-01-01T00:00:00Z2024 Feb2025-04-26T14:25:10.475Z2025-04-06T14:31:53.601ZS-EPMC109341613847450810.3390/molecules29050997