{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(5)"],"submitter":["Lizzadro L"],"funding":["Saxony-Anhalt"],"pubmed_abstract":["The synthesis of a novel disorazole C<sub>1</sub> analogue is described, and its biological activity as a cytotoxic compound is reported. Based on our convergent and flexible route to the disorazole core, we wish to report a robust strategy to synthesize a non-symmetrical disorazole in which we couple one half of the molecule containing the naturally occurring oxazole heterocycle and the second half of the disorazole macrocycle containing a thiazole heterocycle. This resulted in a very unusual non-symmetrical disorazole C<sub>1</sub> analogue containing two different heterocycles, and its biological activity was studied. This provided exciting information about SAR (structure-activity-relationship) for this highly potent class of antitumor compounds."],"journal":["Molecules (Basel, Switzerland)"],"pagination":["1123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10934378"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis of a Non-Symmetrical Disorazole C<sub>1</sub>-Analogue and Its Biological Activity."],"pmcid":["PMC10934378"],"pubmed_authors":["Schinzer D","Stadler M","Spieß O","Lizzadro L","Reinecke S"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of a Non-Symmetrical Disorazole C<sub>1</sub>-Analogue and Its Biological Activity.","description":"The synthesis of a novel disorazole C<sub>1</sub> analogue is described, and its biological activity as a cytotoxic compound is reported. Based on our convergent and flexible route to the disorazole core, we wish to report a robust strategy to synthesize a non-symmetrical disorazole in which we couple one half of the molecule containing the naturally occurring oxazole heterocycle and the second half of the disorazole macrocycle containing a thiazole heterocycle. This resulted in a very unusual non-symmetrical disorazole C<sub>1</sub> analogue containing two different heterocycles, and its biological activity was studied. This provided exciting information about SAR (structure-activity-relationship) for this highly potent class of antitumor compounds.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T21:31:09.271Z","creation":"2025-04-04T21:31:09.271Z"},"accession":"S-EPMC10934378","cross_references":{"pubmed":["38474635"],"doi":["10.3390/molecules29051123"]}}