{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["El Mahdaoui A"],"funding":["Fonds de la Recherche Scientifique—FNRS","COST action","FNRS","European Cooperation in Science and Technology","CNRST","Centre National de la Recherche Scientifique et Technologique"],"pagination":["1186"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10935173"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(5)"],"pubmed_abstract":["In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-<i>N</i>-phenyl-1H-pyrazole-3-carboxamide (<b>L<sub>1</sub></b>) and 1,5-dimethyl-<i>N</i>-propyl-1H-pyrazole-3-carboxamide (<b>L<sub>2</sub></b>), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(<b>L<sub>1</sub></b>)<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>C<sub>1</sub></b>) and a dinuclear complex [Cd<sub>2</sub>(<b>L<sub>2</sub></b>)<sub>2</sub>]Cl<sub>4</sub> (<b>C<sub>2</sub></b>). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, <b>L<sub>1</sub></b> and <b>L<sub>2</sub></b> present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes <b>C<sub>1</sub></b> and <b>C<sub>2</sub></b>."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes."],"pmcid":["PMC10935173"],"funding_grant_id":["CDR J.0064.23","PPR2-MESRSFC-CNRSTP10","EQP U.N027.24","CA21149","PDR T.0095.21, CDR J.0064.23, J.0168.22, EQP U.N027.24","J.0168.22","PDR T.0095.21"],"pubmed_authors":["Garcia Y","Ouahhoud S","Radi S","Draoui Y","El Massaoudi M","Saalaoui E","Benabbes R","El Mahdaoui A","Bentouhami NE","Asehraou A","Robeyns K"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes.","description":"In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-<i>N</i>-phenyl-1H-pyrazole-3-carboxamide (<b>L<sub>1</sub></b>) and 1,5-dimethyl-<i>N</i>-propyl-1H-pyrazole-3-carboxamide (<b>L<sub>2</sub></b>), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(<b>L<sub>1</sub></b>)<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>C<sub>1</sub></b>) and a dinuclear complex [Cd<sub>2</sub>(<b>L<sub>2</sub></b>)<sub>2</sub>]Cl<sub>4</sub> (<b>C<sub>2</sub></b>). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, <b>L<sub>1</sub></b> and <b>L<sub>2</sub></b> present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes <b>C<sub>1</sub></b> and <b>C<sub>2</sub></b>.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-26T03:25:33.333Z","creation":"2025-04-06T14:35:30.958Z"},"accession":"S-EPMC10935173","cross_references":{"pubmed":["38474698"],"doi":["10.3390/molecules29051186"]}}