biostudies-literatureEl Mahdaoui AFonds de la Recherche Scientifique—FNRSCOST actionFNRSEuropean Cooperation in Science and TechnologyCNRSTCentre National de la Recherche Scientifique et Technologique1186https://www.ebi.ac.uk/biostudies/studies/S-EPMC10935173biostudies-literatureUnknown29(5)In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-N-phenyl-1H-pyrazole-3-carboxamide (L1) and 1,5-dimethyl-N-propyl-1H-pyrazole-3-carboxamide (L2), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(L1)2](ClO4)2 (C1) and a dinuclear complex [Cd2(L2)2]Cl4 (C2). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, L1 and L2 present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes C1 and C2.Molecules (Basel, Switzerland)Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes.PMC10935173CDR J.0064.23PPR2-MESRSFC-CNRSTP10EQP U.N027.24CA21149PDR T.0095.21, CDR J.0064.23, J.0168.22, EQP U.N027.24J.0168.22PDR T.0095.21Garcia YOuahhoud SRadi SDraoui YEl Massaoudi MSaalaoui EBenabbes REl Mahdaoui ABentouhami NEAsehraou ARobeyns KfalseSynthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes.In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-N-phenyl-1H-pyrazole-3-carboxamide (L1) and 1,5-dimethyl-N-propyl-1H-pyrazole-3-carboxamide (L2), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(L1)2](ClO4)2 (C1) and a dinuclear complex [Cd2(L2)2]Cl4 (C2). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, L1 and L2 present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes C1 and C2.2024-01-01T00:00:00Z2024 Mar2026-06-26T03:25:33.333Z2025-04-06T14:35:30.958ZS-EPMC109351733847469810.3390/molecules29051186