biostudies-literatureGoncalves BPSunnybrook Research InstituteRockefeller FoundationNational Institutes of HealthCanadian Institutes of Health ResearchInstitute of Cancer ResearchAustralian Research CouncilGoogle.orgHorizon 2020 Framework ProgrammeNational Institute for Health Research (NIHR)Horizon 2020National Institute for Health and Care ResearchKementerian Kesihatan MalaysiaNational Institute for Health Research Health Protection Research UnitLiverpool Experimental Cancer Medicine CentreImperial College LondonBill &amp; Melinda Gates FoundationNorges ForskningsrådUniversity of QueenslandNaval Medical Research Unit—2Medical Research CouncilHealth Research BoardPrince Charles Hospital FoundationMedizinische Universität WienWellcome TrustPublic Health England797-812.e2https://www.ebi.ac.uk/biostudies/studies/S-EPMC10935543biostudies-literatureUnknown4(11)<h4>Background</h4>Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes.<h4>Methods</h4>Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed.<h4>Findings</h4>While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed.<h4>Conclusions</h4>These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history.<h4>Funding</h4>This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the "acknowledgments" section.Med (New York, N.Y.)A multi-country analysis of COVID-19 hospitalizations by vaccination status.PMC10935543200927NIHR203312200907NIHR201395NIHR201385312780OV2170359CTN-2014-12874850APCOV22BGMP0153_21_N2CE170100009MC_PC_19059MR/S032304/1CO-CIN-01C18616 / A25153101003589CTN-2021-010Foti GKho MEMartins ASancho-Shimizu VAlves RShrapnel SStecher SSFraser JFTeixeira JForsyth STessier-Grenier HMustafa DMcArthur CISARIC Clinical Characterisation GroupSequeira TCascao MOpenshaw PTorre MRoessler BHorcajada JPFletcher TDantas JDouglas JJAl-Saba'a YReikvam DHTurgeon AFEscher MRoche-Campo FKraemer MUGDocherty ABWillems SSummers CWhite NAmpaw PCevik MNotari AHashmi MSantos MAl-Fares AFaria PVillar JReyes LFCabrita JD'Aragon FCitarella BWStaudinger TWei JBianco CSuwarti ASalah NASales GLopez Revilla JWDankwa EARangappa RMorton BIppolito MPost AMMohan Shetty DRMudara CShankar ARamalho JIjaz SCavalin RBustos IGKaur AO'Hearn KRoberts SBounphiengsy TPaul MVal-Flores LMcConnochie RMachado SDechert WJenum SZambon MHaber DEdelstein MHennessy MAtlowly MSin WCGreenhalf WArchambault PBaird JKAkwani CChen ASchwameis MMcDonald SEAl Qasim EWainstein MMuller FDudman SFontela PNelder MKhalid INichol ADThomson ECPhonemixay OSibounheuang BMuller KEBertoli GHalpin SVongsouvath MBrazzi LDryden MGavin APetrovic MFarshait NPanda PKPhoutthavong SLind AAlberti ARivera Nunez MACheng MPArcadipane APritchard MGSztajnbok JBitton JBuchtele NCorley AHartman ARewa OKhoo SChaleunphon BManetta FParke RMartin-Loeches IGriffiths FHurd APejkovska MNeumann EDurham LFigueiredo-Mello CTwardowski PPowis JShadowitz ELiang JDasgupta ARossanese ASalazar LBisoffi ZLim WSKandel CCodan CInacio HPovoas DLyons RTorres Santos-Olmo RMMing-Yang Hsu JGuerreiro DBaruch JFuentes NTonby KScott JTLissauer STveita Ade Piero MRen HAlkahlout MHendry RSaviciute EMentzer AJReeve BFerraz MBellemare DMerson LRodari PDyrhol-Riise AMMontrucchio GShaw VEsperatti MSkogen VCavayas AJabal KACaceres ECastanheira NHinton SBassi GLSanchez ETabrizi SLaw ABaillie JKPimentel CKorten VNusantara DUDowning MSadat MPharand SBalan VDowner TIllana CCDuplaix MGermano NSingh MWham MChand MGarces RCAlmasri LRussell CDRafael AJouvet PFowler RANarasimhan MHumaid FBGamble CThwaites RSCardellino CSUllrich RGuerguerian AMGranerud BKSarfo-Mensah SHarrison EMStreinu-Cercel AFernandes MAOcchipinti GWils EJKennon KNg PYSillaots PChristy NGomez-Junyent JHolten ARNorman LWesselius SMunshi LSchwartz GHarrison JRicchiuto AMarshall JLopes DBouhmani DCarney GGu YKlerk BBGoco GArenz LCarrier FMLawrence THorby PRatsep IDagens AGoncalves BPSmith SNasa PDonohue CBeltrame ABach BKeomany SGarcia-Gallo EWilliams BPaulos JFranch-Llasat DBogaert DMajeed NAKlenerman PEstevao JGhadimi MPaxton WABeer NHall MPettersen FOCastaneda SKatz KSpinuzza EKildal ABYiaye TDrake TCarson GGibson JAliudin JWilliams VMarsh LSandhu GCattaneo PKelly SCruz CLee TCGarces RKelly ACabrita JASinatti DWebb SIsidoro TSant Ana Malaque CMKnight SRMoro LWittman JCrowl Gda Silva Filipe ASemple MGKiiza PSemedi BPMcGeer APius RBarbosa NYHamza SArabi YNagpal DKosgei CBarnikel MHeggelund LSteinsvik TMartin-Quiros AFraser CAlessi MYerkovich SArora RPereira RBekken GKShaw CASriskandan SMeyer DCopland MFlynn BG ACanepa CCortegiani AFernandes JLanza MCasimiro JGreen CAQuesada LBegum HPurcell GJaworsky DAmaral MSkeie LGSandulescu OTaleb SPatricio PPollakis GTedder RSKutsogiannis DGrable MHamers RLFriedrich CDubot-Peres AHabraken HK DhangarLeeming GCooke GSBlier CJackson CMeynert AMMihelis EMenon KSahraei VScott-Brown JAirlangga EAnchan AJPiubelli CFairfield CJChow YPde Silva TMoore SSuen JYKalicinska ARahardjani MOliveira LThompson SBuonsenso DVilloldo ACardoso SPanarello GMartucci GCardoso FHardwick HMoore SCOosthuyzen WMurthy SAbdukahil SALefevre BMuhaisen MVarrone MSolomon JGhisulal PKAngheben ANoursadeghi MDaley PHesstvedt LMatthew CPraphasiri VSultana ATurtle LCWChommanam DPitaloka APalmarini MConnor MVitiello CChan ALetizia ABurrell ASolomon TSaba IJassat WValentini PClaure-Del Granado RDe Rose CMcCarthy ARibeiro AFClohisey SDalton JLunn MDalton HHolter JCLee JQuist-Paulsen ECustodio PMarquis COlliaro PLMcKay CDunning JLamontagne FAshley EASarmiento ICERojek AMcLean KABarbalho RFerreira BKartsonaki CDonnelly CACely LMVillanueva JAZahran MDishon YPatterson LDalloul ZDaneman NMayxay MHiggins RKeating SHafez WHiggins DThorpe MDamas JRishu AVieira CGruner HJaber HHo ARobertson DLBarclay WSOng DSYBountthasavong LCaoili JSubekti DHssain AAStuart DCampisi JDouangdala PVidal JEHamdan SStiksrud BAldabbourosama OFerrao JGiani MSong RSchaffer JRego CMPoli SMonteiro FBPires CFaheem AMaslove DMonteiro AAlex BGarcia-Diaz JSanto CEBorges DKumar DGirvan MRossetti MAtique ACsete MSigfrid LUyeki TMMesquita ADenis EfalseA multi-country analysis of COVID-19 hospitalizations by vaccination status.<h4>Background</h4>Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes.<h4>Methods</h4>Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed.<h4>Findings</h4>While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed.<h4>Conclusions</h4>These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history.<h4>Funding</h4>This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the "acknowledgments" section.2023-01-01T00:00:00Z2023 Nov2026-06-26T03:19:07.525Z2025-04-05T12:06:34.647ZS-EPMC109355433773897910.1016/j.medj.2023.08.005