biostudies-literatureKhazali MFNEI NIH HHSNIMH NIH HHS1979-1992.e7https://www.ebi.ac.uk/biostudies/studies/S-EPMC10935574biostudies-literatureUnknown111(12)In the reach and saccade regions of the posterior parietal cortex (PPC), multiregional communication depends on the timing of neuronal activity with respect to beta-frequency (10-30 Hz) local field potential (LFP) activity, termed dual coherence. Neural coherence is believed to reflect neural excitability, whereby spiking tends to occur at a particular phase of LFP activity, but the mechanisms of multiregional dual coherence remain unknown. Here, we investigate dual coherence in the PPC of non-human primates performing eye-hand movements. We computationally model dual coherence in terms of multiregional neural excitability and show that one latent component, a multiregional mode, reflects shared excitability across distributed PPC populations. Analyzing the power in the multiregional mode with respect to different putative cell types reveals significant modulations with the spiking of putative pyramidal neurons and not inhibitory interneurons. These results suggest a specific role for pyramidal neurons in dual coherence supporting multiregional communication in PPC.NeuronPutative cell-type-specific multiregional mode in posterior parietal cortex during coordinated visual behavior.PMC10935574P30 EY013079R01 EY024067R01 EY035826R01 MH087882T32 EY007136Khazali MFFabiszak MMHagan MADean HLPesaran BWong YTfalsePutative cell-type-specific multiregional mode in posterior parietal cortex during coordinated visual behavior.In the reach and saccade regions of the posterior parietal cortex (PPC), multiregional communication depends on the timing of neuronal activity with respect to beta-frequency (10-30 Hz) local field potential (LFP) activity, termed dual coherence. Neural coherence is believed to reflect neural excitability, whereby spiking tends to occur at a particular phase of LFP activity, but the mechanisms of multiregional dual coherence remain unknown. Here, we investigate dual coherence in the PPC of non-human primates performing eye-hand movements. We computationally model dual coherence in terms of multiregional neural excitability and show that one latent component, a multiregional mode, reflects shared excitability across distributed PPC populations. Analyzing the power in the multiregional mode with respect to different putative cell types reveals significant modulations with the spiking of putative pyramidal neurons and not inhibitory interneurons. These results suggest a specific role for pyramidal neurons in dual coherence supporting multiregional communication in PPC.2023-01-01T00:00:00Z2023 Jun2025-04-19T08:36:57.425Z2025-04-19T08:36:57.425ZS-EPMC109355743704408810.1016/j.neuron.2023.03.023