{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bakir G"],"funding":["Natural Sciences and Engineering Research Council of Canada"],"pagination":["355-364"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10935619"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["78(4)"],"pubmed_abstract":["The cell wall integrity (CWI) signaling pathway regulates yeast cell wall biosynthesis, cell division, and responses to external stress. The cell wall, comprised of a dense network of chitin, β-1,3- and β-1,6- glucans, and mannoproteins, is very thin, <100 nm. Alterations in cell wall composition may activate the CWI pathway. <i>Saccharomyces cerevisiae</i>, a model yeast, was used to study the role of individual wall components in altering the structure and biophysical properties of the yeast cell wall. Near-field Fourier transform infrared spectroscopy (nano-FT-IR) was used for the first direct, spectrochemical identification of cell wall composition in a background (wild-type) strain and two deletion mutants from the yeast knock-out collection: <i>kre6</i>Δ and <i>knr4</i>Δ. Killer toxi"],"journal":["Applied spectroscopy"],"pubmed_title":["<i>Saccharomyces cerevisiae</i> CellWall Remodeling in the Absence of Knr4 and Kre6 Revealed by Nano-FourierTransform Infrared Spectroscopy."],"pmcid":["PMC10935619"],"funding_grant_id":["06649-2018","05931-2017"],"pubmed_authors":["Martin-Yken H","Bechtel HA","Bakir G","Gough KM","Dahms TES"],"additional_accession":[]},"is_claimable":false,"name":"<i>Saccharomyces cerevisiae</i> CellWall Remodeling in the Absence of Knr4 and Kre6 Revealed by Nano-FourierTransform Infrared Spectroscopy.","description":"The cell wall integrity (CWI) signaling pathway regulates yeast cell wall biosynthesis, cell division, and responses to external stress. The cell wall, comprised of a dense network of chitin, β-1,3- and β-1,6- glucans, and mannoproteins, is very thin, <100 nm. Alterations in cell wall composition may activate the CWI pathway. <i>Saccharomyces cerevisiae</i>, a model yeast, was used to study the role of individual wall components in altering the structure and biophysical properties of the yeast cell wall. Near-field Fourier transform infrared spectroscopy (nano-FT-IR) was used for the first direct, spectrochemical identification of cell wall composition in a background (wild-type) strain and two deletion mutants from the yeast knock-out collection: <i>kre6</i>Δ and <i>knr4</i>Δ. Killer toxi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-07-15T00:42:27.013Z","creation":"2026-06-27T03:05:46.529Z"},"accession":"S-EPMC10935619","cross_references":{"pubmed":["38378014"],"doi":["10.1177/00037028231213658"]}}