biostudies-literatureSaeedi-Maleki ZTabriz University of Medical Sciences27https://www.ebi.ac.uk/biostudies/studies/S-EPMC10935851biostudies-literatureUnknown10(1)<h4>Purpose</h4>Our objective was to compare the serum Adropin levels between patients with wet-type Age-Related Macular Degeneration (AMD) and otherwise healthy individuals.<h4>Method</h4>The study included 45 patients with wet-type AMD and 45 individuals without age-related macular degeneration. Patients with co-morbidities such as diabetes, hypertension, autoimmune diseases, and a previous history of visual impairment; were excluded. FBS, Hemoglobin A1C (HbA1C), lipid profile, and serum Adropin level were checked.<h4>Results</h4>The mean serum Adropin level of patients with wet-type AMD was significantly lower than the control group (P-value < 0.001). Also, the mean High-sensitivity C-reactive protein ( hsCRP) level and High Density Lipoprotein (HDL) were significantly higher in wet-type AMD patients (P-value = 0.031 and < 0.001 respectively).<h4>Conclusions</h4>In our study, wet-type AMD was associated with a lower level of serum Adropin. Because of Adropin involvement in glucose metabolism and age-related changes, it may have a role in the pathogenesis of AMD, but it requires more investigations at the molecular level to elucidate its function.International journal of retina and vitreousSerum adropin level in wet-type age-related macular degeneration.PMC10935851Tabriz University of Medical SciencesJavadzadeh AMousavi FGhorbanihaghjo ABrumandpur FSaeedi-Maleki ZKhanzadeh SfalseSerum adropin level in wet-type age-related macular degeneration.<h4>Purpose</h4>Our objective was to compare the serum Adropin levels between patients with wet-type Age-Related Macular Degeneration (AMD) and otherwise healthy individuals.<h4>Method</h4>The study included 45 patients with wet-type AMD and 45 individuals without age-related macular degeneration. Patients with co-morbidities such as diabetes, hypertension, autoimmune diseases, and a previous history of visual impairment; were excluded. FBS, Hemoglobin A1C (HbA1C), lipid profile, and serum Adropin level were checked.<h4>Results</h4>The mean serum Adropin level of patients with wet-type AMD was significantly lower than the control group (P-value < 0.001). Also, the mean High-sensitivity C-reactive protein ( hsCRP) level and High Density Lipoprotein (HDL) were significantly higher in wet-type AMD patients (P-value = 0.031 and < 0.001 respectively).<h4>Conclusions</h4>In our study, wet-type AMD was associated with a lower level of serum Adropin. Because of Adropin involvement in glucose metabolism and age-related changes, it may have a role in the pathogenesis of AMD, but it requires more investigations at the molecular level to elucidate its function.2024-01-01T00:00:00Z2024 Mar2026-06-27T03:17:31.293Z2026-06-27T03:06:13.693ZS-EPMC109358513847583810.1186/s40942-024-00543-7