{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li P"],"funding":["Guangdong Provincial Science and Technology Foundation of China","National Natural Science Foundation of China"],"pagination":["e6813"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10935875"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(5)"],"pubmed_abstract":["Background
TFE3 immunohistochemistry (TFE3-IHC) is controversial in the diagnosis of TFE3-rearranged renal cell carcinoma (TFE3-rearranged RCC). This study is to investigate the accuracy and sensitivity of IHC and establish a predictive model to diagnose TFE3-rearranged RCC.Methods
Retrospective analysis was performed by collecting IHC and fluorescence in situ hybridization (FISH) results from 228 patients. IHC results were evaluated using three scoring systems. Scoring system 1 is graded based on nuclear staining intensity, scoring system 2 is graded based on the percentage of stained tumor cell nuclei, and scoring system 3 is graded based on both the nuclear staining intensity and the percentage. We collected patients' IHC results and clinical information. Important varia"],"journal":["Cancer medicine"],"pubmed_title":["A nomogram based on TFE3 IHC results and clinical factors as a preliminary screening scheme for TFE3-rearranged renal cell carcinoma."],"pmcid":["PMC10935875"],"funding_grant_id":["81872094","2017B020227004","81972376","81725016","81772718","2017A030313538","81602219"],"pubmed_authors":["Chen M","Cao J","Xu Q","Mumin MA","Deng Q","Liao B","Li P","Huang K","Jiang Z","Zhu J","Liang H","Luo J","Cao Y","Chen W","Wang Y","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"A nomogram based on TFE3 IHC results and clinical factors as a preliminary screening scheme for TFE3-rearranged renal cell carcinoma.","description":"Background
TFE3 immunohistochemistry (TFE3-IHC) is controversial in the diagnosis of TFE3-rearranged renal cell carcinoma (TFE3-rearranged RCC). This study is to investigate the accuracy and sensitivity of IHC and establish a predictive model to diagnose TFE3-rearranged RCC.Methods
Retrospective analysis was performed by collecting IHC and fluorescence in situ hybridization (FISH) results from 228 patients. IHC results were evaluated using three scoring systems. Scoring system 1 is graded based on nuclear staining intensity, scoring system 2 is graded based on the percentage of stained tumor cell nuclei, and scoring system 3 is graded based on both the nuclear staining intensity and the percentage. We collected patients' IHC results and clinical information. Important varia","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-15T14:57:23.465Z","creation":"2026-07-06T03:09:21.532Z"},"accession":"S-EPMC10935875","cross_references":{"pubmed":["38477529"],"doi":["10.1002/cam4.6813"]}}