biostudies-literatureLi PGuangdong Provincial Science and Technology Foundation of ChinaNational Natural Science Foundation of Chinae6813https://www.ebi.ac.uk/biostudies/studies/S-EPMC10935875biostudies-literatureUnknown13(5)<h4>Background</h4>TFE3 immunohistochemistry (TFE3-IHC) is controversial in the diagnosis of TFE3-rearranged renal cell carcinoma (TFE3-rearranged RCC). This study is to investigate the accuracy and sensitivity of IHC and establish a predictive model to diagnose TFE3-rearranged RCC.<h4>Methods</h4>Retrospective analysis was performed by collecting IHC and fluorescence in situ hybridization (FISH) results from 228 patients. IHC results were evaluated using three scoring systems. Scoring system 1 is graded based on nuclear staining intensity, scoring system 2 is graded based on the percentage of stained tumor cell nuclei, and scoring system 3 is graded based on both the nuclear staining intensity and the percentage. We collected patients' IHC results and clinical information. Important variaCancer medicineA nomogram based on TFE3 IHC results and clinical factors as a preliminary screening scheme for TFE3-rearranged renal cell carcinoma.PMC10935875818720942017B0202270048197237681725016817727182017A03031353881602219Chen MCao JXu QMumin MADeng QLiao BLi PHuang KJiang ZZhu JLiang HLuo JCao YChen WWang YWang ZfalseA nomogram based on TFE3 IHC results and clinical factors as a preliminary screening scheme for TFE3-rearranged renal cell carcinoma.<h4>Background</h4>TFE3 immunohistochemistry (TFE3-IHC) is controversial in the diagnosis of TFE3-rearranged renal cell carcinoma (TFE3-rearranged RCC). This study is to investigate the accuracy and sensitivity of IHC and establish a predictive model to diagnose TFE3-rearranged RCC.<h4>Methods</h4>Retrospective analysis was performed by collecting IHC and fluorescence in situ hybridization (FISH) results from 228 patients. IHC results were evaluated using three scoring systems. Scoring system 1 is graded based on nuclear staining intensity, scoring system 2 is graded based on the percentage of stained tumor cell nuclei, and scoring system 3 is graded based on both the nuclear staining intensity and the percentage. We collected patients' IHC results and clinical information. Important varia2024-01-01T00:00:00Z2024 Mar2026-07-15T14:57:23.465Z2026-07-06T03:09:21.532ZS-EPMC109358753847752910.1002/cam4.6813