{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["Wang R"],"pubmed_abstract":["<h4>Background</h4>Bladder cancer (BC) is one of the most common malignancies of the genitourinary system. Phosphofructokinase 1 (PFK-1) is one of member of PFK, which plays an important role in reprogramming cancer metabolism, such as lactylation modification. Zinc finger E-box-binding homeobox 1 (ZEB1) has been demonstrated to be a oncogene in many cancers. Therefore, this study was performed to explore the effects of PFK-1 on the lactylation of ZEB1 in BC development.<h4>Methods</h4>Cell viability was measured using the CCK-8 kit. The glucose assay kit and lactate assay kit were used to detect glucose utilization and lactate production. The DNA was purified and quantified by qRT-PCR.<h4>Results</h4>In the present study, we found that ZEB1 expression levels were significantly elevated in"],"journal":["BMC urology"],"pagination":["59"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10935987"],"repository":["biostudies-literature"],"pubmed_title":["The mechanism of PFK-1 in the occurrence and development of bladder cancer by regulating ZEB1 lactylation."],"pmcid":["PMC10935987"],"pubmed_authors":["Yang Z","Wang R","Cao J","Xu F","Hu L","She Y"],"additional_accession":[]},"is_claimable":false,"name":"The mechanism of PFK-1 in the occurrence and development of bladder cancer by regulating ZEB1 lactylation.","description":"<h4>Background</h4>Bladder cancer (BC) is one of the most common malignancies of the genitourinary system. Phosphofructokinase 1 (PFK-1) is one of member of PFK, which plays an important role in reprogramming cancer metabolism, such as lactylation modification. Zinc finger E-box-binding homeobox 1 (ZEB1) has been demonstrated to be a oncogene in many cancers. Therefore, this study was performed to explore the effects of PFK-1 on the lactylation of ZEB1 in BC development.<h4>Methods</h4>Cell viability was measured using the CCK-8 kit. The glucose assay kit and lactate assay kit were used to detect glucose utilization and lactate production. The DNA was purified and quantified by qRT-PCR.<h4>Results</h4>In the present study, we found that ZEB1 expression levels were significantly elevated in","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-14T21:22:16.197Z","creation":"2026-06-24T03:12:51.19Z"},"accession":"S-EPMC10935987","cross_references":{"pubmed":["38481182"],"doi":["10.1186/s12894-024-01444-5"]}}