{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Varshney D"],"pubmed_abstract":["<h4>Objectives</h4>The objective of this study is to analyze the association between <i>TLR2 deletion (-196 to -174)</i> and <i>TLR1 743 A > G</i> gene polymorphism with drug resistant tuberculosis (PTB, MDR-TB, and XDR-TB) in a population from Agra, Uttar Pradesh.<h4>Methods</h4>The present case-control study included 101 pulmonary TB patients, 104 multidrug-resistant TB patients, 48 extremely drug-resistant TB patients, and 130 healthy and unrelated controls residing in the same locality. The genotyping method for <i>TLR2 deletion (-196 to -174)</i> was carried out by allele-specific polymerase chain reaction (PCR), and <i>TLR1 743 A > G</i> gene polymorphism was performed by hybridization probe chemistry in Roche Real-Time PCR. Genotype and allele frequencies were analyzed by the chi-sq"],"journal":["Frontiers in microbiology"],"pagination":["1305974"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10936010"],"repository":["biostudies-literature"],"pubmed_title":["<i>Toll-like receptor 2 (-196 to -174) del</i> and <i>TLR1 743 A > G</i> gene polymorphism-a possible association with drug-resistant tuberculosis in the north Indian population."],"pmcid":["PMC10936010"],"pubmed_authors":["Mohanty KK","Varshney N","Sinha E","Varshney D","Barik SK","Singh SV","Kumar S"],"additional_accession":[]},"is_claimable":false,"name":"<i>Toll-like receptor 2 (-196 to -174) del</i> and <i>TLR1 743 A > G</i> gene polymorphism-a possible association with drug-resistant tuberculosis in the north Indian population.","description":"<h4>Objectives</h4>The objective of this study is to analyze the association between <i>TLR2 deletion (-196 to -174)</i> and <i>TLR1 743 A > G</i> gene polymorphism with drug resistant tuberculosis (PTB, MDR-TB, and XDR-TB) in a population from Agra, Uttar Pradesh.<h4>Methods</h4>The present case-control study included 101 pulmonary TB patients, 104 multidrug-resistant TB patients, 48 extremely drug-resistant TB patients, and 130 healthy and unrelated controls residing in the same locality. The genotyping method for <i>TLR2 deletion (-196 to -174)</i> was carried out by allele-specific polymerase chain reaction (PCR), and <i>TLR1 743 A > G</i> gene polymorphism was performed by hybridization probe chemistry in Roche Real-Time PCR. Genotype and allele frequencies were analyzed by the chi-sq","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-05T12:06:18.896Z","creation":"2025-04-05T12:06:18.896Z"},"accession":"S-EPMC10936010","cross_references":{"pubmed":["38481606"],"doi":["10.3389/fmicb.2023.1305974"]}}