biostudies-literatureUnknown14Varshney D<h4>Objectives</h4>The objective of this study is to analyze the association between <i>TLR2 deletion (-196 to -174)</i> and <i>TLR1 743 A > G</i> gene polymorphism with drug resistant tuberculosis (PTB, MDR-TB, and XDR-TB) in a population from Agra, Uttar Pradesh.<h4>Methods</h4>The present case-control study included 101 pulmonary TB patients, 104 multidrug-resistant TB patients, 48 extremely drug-resistant TB patients, and 130 healthy and unrelated controls residing in the same locality. The genotyping method for <i>TLR2 deletion (-196 to -174)</i> was carried out by allele-specific polymerase chain reaction (PCR), and <i>TLR1 743 A > G</i> gene polymorphism was performed by hybridization probe chemistry in Roche Real-Time PCR. Genotype and allele frequencies were analyzed by the chi-sqFrontiers in microbiology1305974https://www.ebi.ac.uk/biostudies/studies/S-EPMC10936010biostudies-literature<i>Toll-like receptor 2 (-196 to -174) del</i> and <i>TLR1 743 A > G</i> gene polymorphism-a possible association with drug-resistant tuberculosis in the north Indian population.PMC10936010Mohanty KKVarshney NSinha EVarshney DBarik SKSingh SVKumar Sfalse<i>Toll-like receptor 2 (-196 to -174) del</i> and <i>TLR1 743 A > G</i> gene polymorphism-a possible association with drug-resistant tuberculosis in the north Indian population.<h4>Objectives</h4>The objective of this study is to analyze the association between <i>TLR2 deletion (-196 to -174)</i> and <i>TLR1 743 A > G</i> gene polymorphism with drug resistant tuberculosis (PTB, MDR-TB, and XDR-TB) in a population from Agra, Uttar Pradesh.<h4>Methods</h4>The present case-control study included 101 pulmonary TB patients, 104 multidrug-resistant TB patients, 48 extremely drug-resistant TB patients, and 130 healthy and unrelated controls residing in the same locality. The genotyping method for <i>TLR2 deletion (-196 to -174)</i> was carried out by allele-specific polymerase chain reaction (PCR), and <i>TLR1 743 A > G</i> gene polymorphism was performed by hybridization probe chemistry in Roche Real-Time PCR. Genotype and allele frequencies were analyzed by the chi-sq2023-01-01T00:00:00Z20232025-04-05T12:06:18.896Z2025-04-05T12:06:18.896ZS-EPMC109360103848160610.3389/fmicb.2023.1305974