biostudies-literatureSarasa-Buisan CMinisterio de Ciencia, Innovación y Universidades (MCIU)Ministerio de Ciencia, Innovación y UniversidadesGobierno de Aragón (Government of Aragon)National Science Foundation (NSF)National Science FoundationGobierno de Aragóne0323123https://www.ebi.ac.uk/biostudies/studies/S-EPMC10936207biostudies-literatureUnknown15(3)Microbial extracellular proteins and metabolites provide valuable information concerning how microbes adapt to changing environments. In cyanobacteria, dynamic acclimation strategies involve a variety of regulatory mechanisms, being ferric uptake regulator proteins as key players in this process. In the nitrogen-fixing cyanobacterium <i>Anabaena</i> sp. strain PCC 7120, FurC (PerR) is a global regulator that modulates the peroxide response and several genes involved in photosynthesis and nitrogen metabolism. To investigate the possible role of FurC in shaping the extracellular environment of <i>Anabaena</i>, the analysis of the extracellular metabolites and proteins of a <i>furC</i>-overexpressing variant was compared to that of the wild-type strain. There were 96 differentially abundant pmBioFurC (PerR) contributes to the regulation of peptidoglycan remodeling and intercellular molecular transfer in the cyanobacterium <i>Anabaena</i> sp. strain PCC 7120.PMC10936207E35_20R Biología estructuralPID2019-104889GB-I00DMR-1933525 GlycoMIPPID2020-118595GB-I00Nieves-Morion MArevalo SSevilla EHelm RFFillat MFSarasa-Buisan CLuque IfalseFurC (PerR) contributes to the regulation of peptidoglycan remodeling and intercellular molecular transfer in the cyanobacterium <i>Anabaena</i> sp. strain PCC 7120.Microbial extracellular proteins and metabolites provide valuable information concerning how microbes adapt to changing environments. In cyanobacteria, dynamic acclimation strategies involve a variety of regulatory mechanisms, being ferric uptake regulator proteins as key players in this process. In the nitrogen-fixing cyanobacterium <i>Anabaena</i> sp. strain PCC 7120, FurC (PerR) is a global regulator that modulates the peroxide response and several genes involved in photosynthesis and nitrogen metabolism. To investigate the possible role of FurC in shaping the extracellular environment of <i>Anabaena</i>, the analysis of the extracellular metabolites and proteins of a <i>furC</i>-overexpressing variant was compared to that of the wild-type strain. There were 96 differentially abundant p2024-01-01T00:00:00Z2024 Mar2026-07-15T13:51:13.917Z2026-07-05T03:11:24.59ZS-EPMC109362073833437710.1128/mbio.03231-23