biostudies-literatureMiley KMNIMH NIH HHSNational Institute of Mental Health139-147https://www.ebi.ac.uk/biostudies/studies/S-EPMC10936711biostudies-literatureUnknown85<h4>Objective</h4>To estimate 30-year CVD risk and modifiable risk factors in young adults with serious mental illness (SMI) versus those without, and assess variations in CVD risk by race, ethnicity, and sex.<h4>Method</h4>In this cross-sectional study, we estimated and compared the Framingham 30-year CVD risk score and individual modifiable CVD risk factors in young adult (20-39 years) primary care patients with and without SMI at two US healthcare systems (January 2016-Septemeber 2018). Interaction terms assessed whether the SMI-risk association differed across demographic groups.<h4>Results</h4>Covariate-adjusted 30-year CVD risk was significantly higher for those with (n=4228) versus those without (n=155,363) SMI (RR 1.28, 95% CI [1.26, 1.30]). Patients with SMI had higher rates of hypertension (OR 2.02 [1.7, 2.39]), diabetes (OR 3.14 [2.59, 3.82]), obesity (OR 1.93 [1.8, 2.07]), and smoking (OR 4.94 [4.6, 5.36]). The increased 30-year CVD risk associated with SMI varied significantly by race and sex: there was an 8% higher risk in Black compared to White patients (RR 1.08, [1.04, 1.12]) and a 9% lower risk in men compared to women (RR 0.91 [0.88, 0.94]).<h4>Conclusions</h4>Young adults with SMI are at increased 30-year risk of CVD, and further disparities exist for Black individuals and women.General hospital psychiatry30-year Cardiovascular Disease Risk for Young Adults with Serious Mental Illness.PMC10936711U19 MH092201U19MH092201Rossom RCHooker SACrain ALO'Connor PJHaapala JLBond DJMiley KMfalse30-year Cardiovascular Disease Risk for Young Adults with Serious Mental Illness.<h4>Objective</h4>To estimate 30-year CVD risk and modifiable risk factors in young adults with serious mental illness (SMI) versus those without, and assess variations in CVD risk by race, ethnicity, and sex.<h4>Method</h4>In this cross-sectional study, we estimated and compared the Framingham 30-year CVD risk score and individual modifiable CVD risk factors in young adult (20-39 years) primary care patients with and without SMI at two US healthcare systems (January 2016-Septemeber 2018). Interaction terms assessed whether the SMI-risk association differed across demographic groups.<h4>Results</h4>Covariate-adjusted 30-year CVD risk was significantly higher for those with (n=4228) versus those without (n=155,363) SMI (RR 1.28, 95% CI [1.26, 1.30]). Patients with SMI had higher rates of hypertension (OR 2.02 [1.7, 2.39]), diabetes (OR 3.14 [2.59, 3.82]), obesity (OR 1.93 [1.8, 2.07]), and smoking (OR 4.94 [4.6, 5.36]). The increased 30-year CVD risk associated with SMI varied significantly by race and sex: there was an 8% higher risk in Black compared to White patients (RR 1.08, [1.04, 1.12]) and a 9% lower risk in men compared to women (RR 0.91 [0.88, 0.94]).<h4>Conclusions</h4>Young adults with SMI are at increased 30-year risk of CVD, and further disparities exist for Black individuals and women.2023-01-01T00:00:00Z2023 Nov-Dec2025-04-19T18:12:05.799Z2025-04-19T18:12:05.799ZS-EPMC109367113848765210.1016/j.genhosppsych.2023.10.015