{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["All of Us Research Program Genomics Investigators"],"funding":["NICHD NIH HHS","NHGRI NIH HHS","NIH HHS"],"pagination":["340-346"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10937371"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["627(8003)"],"pubmed_abstract":["Comprehensively mapping the genetic basis of human disease across diverse individuals is a long-standing goal for the field of human genetics<sup>1-4</sup>. The All of Us Research Program is a longitudinal cohort study aiming to enrol a diverse group of at least one million individuals across the USA to accelerate biomedical research and improve human health<sup>5,6</sup>. Here we describe the programme's genomics data release of 245,388 clinical-grade genome sequences. This resource is unique in its diversity as 77% of participants are from communities that are historically under-represented in biomedical research and 46% are individuals from under-represented racial and ethnic minorities. All of Us identified more than 1 billion genetic variants, including more than 275 million previousl"],"journal":["Nature"],"pubmed_title":["Genomic data in the All of Us Research Program."],"pmcid":["PMC10937371"],"funding_grant_id":["OT2 OD002751","RM1 HG012334","OT2 OD002750","OT2 OD026548","OT2 OD025337","OT2 OD025315","OT2 OD026549","OT2 OD025277","OT2 OD025276","U24 OD023121","U24 OD023163","U2C OD023196","OT2 OD026555","OT2 OD026554","OT2 OD026557","OT2 OD026556","OT2 OD023205","OT2 OD023206","OT2 OD026551","OT2 OD026550","OT2 OD026553","OT2 OD026552","P50 HD103538","U24 OD023176","OT2 OD035404","DP2 OD002750","OT2 OD002748"],"pubmed_authors":["Vasta V","Krumm N","Zhang J","Nambiar S","Carroll RJ","Gibbs RA","All of Us Research Program Genomics Investigators","Nagar SD","Blegen AL","Griffith SML","Wirkus SJ","Haessly A","Hatcher A","Ling H","Rura S","Lockwood CM","Mawhinney MZ","Gatzen M","Doheny KF","Walker K","Kachulis C","Aster MMT","Meller R","Lebo MS","Davis CP","Kovar CL","Hu J","Gauthier LD","Ramirez AH","Lennon NJ","Degatano K","Roden DM","Ginsburg GS","Henricks E","Adams MK","Dugan S","Shergill A","Philippakis A","Murugan M","Frazar CD","Linder JE","Jarvik GP","McDonough S","Smith JD","Buchan JG","Lee SK","Hsu E","Murray ML","Brandt GR","Cremer A","Covarrubias M","Denny JC","Musick A","Leistritz D","Steeves M","Condon HR","Rehm HL","Larsson K","Boerwinkle E","Venner E","Glazer D","Green AE","Gabriel S","Ehmen BW","Able A","Wang X","Gupta N","Wang Y","Zhou AY","Meyer JG","Sharma S","Ozenberger B","Metcalf GA","Radhakrishnan A","Cibulskis K","Pritchard CC","Harris PA","Richardson MA","Thibodeau SN","Patterson KE","Grant GB","Lim S","Khan Z","Lunt C","Harrison SM","Asch R","Shirts BH","Topper S","Neben CL","Mayo KR","Albach CH","Rosenthal EA","Banks E","Basford M","Austin-Tse C","Jordan IK","Schwartz S","Doddapaneni H","Lichtenstein L","Wagner VA","McGee S","Muzny DM","Wheeler MM","Wise AL","Baalawi W","Cicek MS","Choi SH","Eichler EE","Dillon MK","Bick AG"],"additional_accession":[]},"is_claimable":false,"name":"Genomic data in the All of Us Research Program.","description":"Comprehensively mapping the genetic basis of human disease across diverse individuals is a long-standing goal for the field of human genetics<sup>1-4</sup>. The All of Us Research Program is a longitudinal cohort study aiming to enrol a diverse group of at least one million individuals across the USA to accelerate biomedical research and improve human health<sup>5,6</sup>. Here we describe the programme's genomics data release of 245,388 clinical-grade genome sequences. This resource is unique in its diversity as 77% of participants are from communities that are historically under-represented in biomedical research and 46% are individuals from under-represented racial and ethnic minorities. All of Us identified more than 1 billion genetic variants, including more than 275 million previousl","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-02T22:53:41.59Z","creation":"2024-10-17T16:50:30.472Z"},"accession":"S-EPMC10937371","cross_references":{"pubmed":["38374255"],"doi":["10.1038/s41586-023-06957-x"]}}