biostudies-literatureAll of Us Research Program Genomics InvestigatorsNICHD NIH HHSNHGRI NIH HHSNIH HHS340-346https://www.ebi.ac.uk/biostudies/studies/S-EPMC10937371biostudies-literatureUnknown627(8003)Comprehensively mapping the genetic basis of human disease across diverse individuals is a long-standing goal for the field of human genetics^1-4. The All of Us Research Program is a longitudinal cohort study aiming to enrol a diverse group of at least one million individuals across the USA to accelerate biomedical research and improve human health^5,6. Here we describe the programme's genomics data release of 245,388 clinical-grade genome sequences. This resource is unique in its diversity as 77% of participants are from communities that are historically under-represented in biomedical research and 46% are individuals from under-represented racial and ethnic minorities. All of Us identified more than 1 billion genetic variants, including more than 275 million previouslNatureGenomic data in the All of Us Research Program.PMC10937371OT2 OD002751RM1 HG012334OT2 OD002750OT2 OD026548OT2 OD025337OT2 OD025315OT2 OD026549OT2 OD025277OT2 OD025276U24 OD023121U24 OD023163U2C OD023196OT2 OD026555OT2 OD026554OT2 OD026557OT2 OD026556OT2 OD023205OT2 OD023206OT2 OD026551OT2 OD026550OT2 OD026553OT2 OD026552P50 HD103538U24 OD023176OT2 OD035404DP2 OD002750OT2 OD002748Vasta VKrumm NZhang JNambiar SCarroll RJGibbs RAAll of Us Research Program Genomics InvestigatorsNagar SDBlegen ALGriffith SMLWirkus SJHaessly AHatcher ALing HRura SLockwood CMMawhinney MZGatzen MDoheny KFWalker KKachulis CAster MMTMeller RLebo MSDavis CPKovar CLHu JGauthier LDRamirez AHLennon NJDegatano KRoden DMGinsburg GSHenricks EAdams MKDugan SShergill APhilippakis AMurugan MFrazar CDLinder JEJarvik GPMcDonough SSmith JDBuchan JGLee SKHsu EMurray MLBrandt GRCremer ACovarrubias MDenny JCMusick ALeistritz DSteeves MCondon HRRehm HLLarsson KBoerwinkle EVenner EGlazer DGreen AEGabriel SEhmen BWAble AWang XGupta NWang YZhou AYMeyer JGSharma SOzenberger BMetcalf GARadhakrishnan ACibulskis KPritchard CCHarris PARichardson MAThibodeau SNPatterson KEGrant GBLim SKhan ZLunt CHarrison SMAsch RShirts BHTopper SNeben CLMayo KRAlbach CHRosenthal EABanks EBasford MAustin-Tse CJordan IKSchwartz SDoddapaneni HLichtenstein LWagner VAMcGee SMuzny DMWheeler MMWise ALBaalawi WCicek MSChoi SHEichler EEDillon MKBick AGfalseGenomic data in the All of Us Research Program.Comprehensively mapping the genetic basis of human disease across diverse individuals is a long-standing goal for the field of human genetics^1-4. The All of Us Research Program is a longitudinal cohort study aiming to enrol a diverse group of at least one million individuals across the USA to accelerate biomedical research and improve human health^5,6. Here we describe the programme's genomics data release of 245,388 clinical-grade genome sequences. This resource is unique in its diversity as 77% of participants are from communities that are historically under-represented in biomedical research and 46% are individuals from under-represented racial and ethnic minorities. All of Us identified more than 1 billion genetic variants, including more than 275 million previousl2024-01-01T00:00:00Z2024 Mar2026-06-02T22:53:41.59Z2024-10-17T16:50:30.472ZS-EPMC109373713837425510.1038/s41586-023-06957-x