{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["627(8003)"],"submitter":["Kronenfeld JM"],"pubmed_abstract":["Particle fabrication has attracted recent attention owing to its diverse applications in bioengineering<sup>1,2</sup>, drug and vaccine delivery<sup>3-5</sup>, microfluidics<sup>6,7</sup>, granular systems<sup>8,9</sup>, self-assembly<sup>5,10,11</sup>, microelectronics<sup>12,13</sup> and abrasives<sup>14</sup>. Herein we introduce a scalable, high-resolution, 3D printing technique for the fabrication of shape-specific particles based on roll-to-roll continuous liquid interface production (r2rCLIP). We demonstrate r2rCLIP using single-digit, micron-resolution optics in combination with a continuous roll of film (in lieu of a static platform), enabling the rapidly permutable fabrication and harvesting of shape-specific particles from a variety of materials and with complex geometries, including geometries not possible to achieve with advanced mould-based techniques. We demonstrate r2rCLIP production of mouldable and non-mouldable shapes with voxel sizes as small as 2.0 × 2.0 µm<sup>2</sup> in the print plane and 1.1 ± 0.3 µm unsupported thickness, at speeds of up to 1,000,000 particles per day. Such microscopic particles with permutable, intricate designs enable direct integration within biomedical, analytical and advanced materials applications."],"journal":["Nature"],"pagination":["306-312"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10937373"],"repository":["biostudies-literature"],"pubmed_title":["Roll-to-roll, high-resolution 3D printing of shape-specific particles."],"pmcid":["PMC10937373"],"pubmed_authors":["Kronenfeld JM","DeSimone JM","Rother L","Dulay MT","Saccone MA"],"additional_accession":[]},"is_claimable":false,"name":"Roll-to-roll, high-resolution 3D printing of shape-specific particles.","description":"Particle fabrication has attracted recent attention owing to its diverse applications in bioengineering<sup>1,2</sup>, drug and vaccine delivery<sup>3-5</sup>, microfluidics<sup>6,7</sup>, granular systems<sup>8,9</sup>, self-assembly<sup>5,10,11</sup>, microelectronics<sup>12,13</sup> and abrasives<sup>14</sup>. Herein we introduce a scalable, high-resolution, 3D printing technique for the fabrication of shape-specific particles based on roll-to-roll continuous liquid interface production (r2rCLIP). We demonstrate r2rCLIP using single-digit, micron-resolution optics in combination with a continuous roll of film (in lieu of a static platform), enabling the rapidly permutable fabrication and harvesting of shape-specific particles from a variety of materials and with complex geometries, including geometries not possible to achieve with advanced mould-based techniques. We demonstrate r2rCLIP production of mouldable and non-mouldable shapes with voxel sizes as small as 2.0 × 2.0 µm<sup>2</sup> in the print plane and 1.1 ± 0.3 µm unsupported thickness, at speeds of up to 1,000,000 particles per day. Such microscopic particles with permutable, intricate designs enable direct integration within biomedical, analytical and advanced materials applications.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-27T03:07:35.744Z","creation":"2026-06-27T03:05:17.282Z"},"accession":"S-EPMC10937373","cross_references":{"pubmed":["38480965"],"doi":["10.1038/s41586-024-07061-4"]}}