{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jing ZL"],"funding":["the National Natural Science Foundation of China"],"pagination":["6053"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10937991"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["The bioactivity of interferon-γ (IFN-γ) in cancer cells in the tumor microenvironment (TME) is not well understood in the current immunotherapy era. We found that IFN-γ has an immunosuppressive effect on colorectal cancer (CRC) cells. The tumor volume in immunocompetent mice was significantly increased after subcutaneous implantation of murine CRC cells followed by IFN-γ stimulation, and RNA sequencing showed high expression of B7 homologous protein 4 (B7H4) in these tumors. B7H4 promotes CRC cell growth by inhibiting the release of granzyme B (GzmB) from CD8<sup>+</sup> T cells and accelerating apoptosis in CD8<sup>+</sup> T cells. Furthermore, interferon regulatory factor 1 (IRF1), which binds to the B7H4 promoter, is positively associated with IFN-γ stimulation-induced expression of B7H"],"journal":["Scientific reports"],"pubmed_title":["Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells."],"pmcid":["PMC10937991"],"funding_grant_id":["81672453","81702359"],"pubmed_authors":["Liu GL","Feng N","Zhou N","Xu DY","Ma LL","Tang N","Lei Y","Deng YJ","Jing ZL","Tang MS","Tong GH"],"additional_accession":[]},"is_claimable":false,"name":"Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells.","description":"The bioactivity of interferon-γ (IFN-γ) in cancer cells in the tumor microenvironment (TME) is not well understood in the current immunotherapy era. We found that IFN-γ has an immunosuppressive effect on colorectal cancer (CRC) cells. The tumor volume in immunocompetent mice was significantly increased after subcutaneous implantation of murine CRC cells followed by IFN-γ stimulation, and RNA sequencing showed high expression of B7 homologous protein 4 (B7H4) in these tumors. B7H4 promotes CRC cell growth by inhibiting the release of granzyme B (GzmB) from CD8<sup>+</sup> T cells and accelerating apoptosis in CD8<sup>+</sup> T cells. Furthermore, interferon regulatory factor 1 (IRF1), which binds to the B7H4 promoter, is positively associated with IFN-γ stimulation-induced expression of B7H","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-14T21:00:30.719Z","creation":"2026-06-24T03:07:05.953Z"},"accession":"S-EPMC10937991","cross_references":{"pubmed":["38480774"],"doi":["10.1038/s41598-024-56681-3"]}}