{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Inman JL"],"funding":["Intelligence Advanced Research Projects Activity","NIGMS NIH HHS"],"pagination":["6119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10937999"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Non-invasive methods of detecting radiation exposure show promise to improve upon current approaches to biological dosimetry in ease, speed, and accuracy. Here we developed a pipeline that employs Fourier transform infrared (FTIR) spectroscopy in the mid-infrared spectrum to identify a signature of low dose ionizing radiation exposure in mouse ear pinnae over time. Mice exposed to 0.1 to 2 Gy total body irradiation were repeatedly measured by FTIR at the stratum corneum of the ear pinnae. We found significant discriminative power for all doses and time-points out to 90 days after exposure. Classification accuracy was maximized when testing 14 days after exposure (specificity > 0.9 with a sensitivity threshold of 0.9) and dropped by roughly 30% sensitivity at 90 days. Infrared frequencies p"],"journal":["Scientific reports"],"pubmed_title":["Long-term, non-invasive FTIR detection of low-dose ionizing radiation exposure."],"pmcid":["PMC10937999"],"funding_grant_id":["20008-D2021-2107310008","R01 GM126218"],"pubmed_authors":["Inman JL","Ghosh D","Celniker SE","Zwart PH","Nakamura K","Wan KH","De Chant J","Chen L","Snijders AM","Mao JH","Obst-Huebl L","Ralston CY","Brydon E","Holman HN","Wu Y","Chang H","Brown JB"],"additional_accession":[]},"is_claimable":false,"name":"Long-term, non-invasive FTIR detection of low-dose ionizing radiation exposure.","description":"Non-invasive methods of detecting radiation exposure show promise to improve upon current approaches to biological dosimetry in ease, speed, and accuracy. Here we developed a pipeline that employs Fourier transform infrared (FTIR) spectroscopy in the mid-infrared spectrum to identify a signature of low dose ionizing radiation exposure in mouse ear pinnae over time. Mice exposed to 0.1 to 2 Gy total body irradiation were repeatedly measured by FTIR at the stratum corneum of the ear pinnae. We found significant discriminative power for all doses and time-points out to 90 days after exposure. Classification accuracy was maximized when testing 14 days after exposure (specificity > 0.9 with a sensitivity threshold of 0.9) and dropped by roughly 30% sensitivity at 90 days. Infrared frequencies p","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-14T20:57:15.529Z","creation":"2026-06-24T03:06:59.985Z"},"accession":"S-EPMC10937999","cross_references":{"pubmed":["38480827"],"doi":["10.1038/s41598-024-56491-7"]}}