{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Benlarbi M"],"funding":["NIA NIH HHS","NIAID NIH HHS","BioRender","CIHR"],"pagination":["763-774"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10938206"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["229(3)"],"pubmed_abstract":["<h4>Background</h4>Chronic inflammation persists in some people living with human immunodeficiency virus (HIV) during antiretroviral therapy and is associated with premature aging. The glycoprotein 120 (gp120) subunit of HIV-1 envelope sheds and can be detected in plasma, showing immunomodulatory properties even in the absence of detectable viremia. We evaluated whether plasma soluble gp120 (sgp120) and a family of gp120-specific anti-cluster A antibodies, linked to CD4 depletion in vitro, contribute to chronic inflammation, immune dysfunction, and subclinical cardiovascular disease in participants of the Canadian HIV and Aging Cohort Study with undetectable viremia.<h4>Methods</h4>Cross-sectional assessment of sgp120 and anti-cluster A antibodies was performed in 386 individuals from the "],"journal":["The Journal of infectious diseases"],"pubmed_title":["Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia."],"pmcid":["PMC10938206"],"funding_grant_id":["UM1 AI164562","R01 AI129769","R01 AI148379","UM1 AI164560","R01 AI150322","R01 AI174908","R01 AI176531","R01 AG054324","R01 AI116274"],"pubmed_authors":["Maldarelli F","Kaufmann DE","Tolbert WD","Clark A","Sylla M","Baril JG","Benlarbi M","Gendron-Lepage G","Finzi A","Richard J","Duerr R","Durand M","Verly MM","Fromentin R","Turcotte I","Tremblay C","Pazgier M","Chomont N","Chartrand-Lefebvre C","Begin P","Trottier S","Prevost J","Messier-Peet M","Mothes W","Bourassa C","Trottier B","Guertin C","El-Far M"],"additional_accession":[]},"is_claimable":false,"name":"Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia.","description":"<h4>Background</h4>Chronic inflammation persists in some people living with human immunodeficiency virus (HIV) during antiretroviral therapy and is associated with premature aging. The glycoprotein 120 (gp120) subunit of HIV-1 envelope sheds and can be detected in plasma, showing immunomodulatory properties even in the absence of detectable viremia. We evaluated whether plasma soluble gp120 (sgp120) and a family of gp120-specific anti-cluster A antibodies, linked to CD4 depletion in vitro, contribute to chronic inflammation, immune dysfunction, and subclinical cardiovascular disease in participants of the Canadian HIV and Aging Cohort Study with undetectable viremia.<h4>Methods</h4>Cross-sectional assessment of sgp120 and anti-cluster A antibodies was performed in 386 individuals from the ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-24T03:09:37.858Z","creation":"2026-06-24T03:06:26.637Z"},"accession":"S-EPMC10938206","cross_references":{"pubmed":["38035854"],"doi":["10.1093/infdis/jiad503"]}}