biostudies-literatureBenlarbi MNIA NIH HHSNIAID NIH HHSBioRenderCIHR763-774https://www.ebi.ac.uk/biostudies/studies/S-EPMC10938206biostudies-literatureUnknown229(3)<h4>Background</h4>Chronic inflammation persists in some people living with human immunodeficiency virus (HIV) during antiretroviral therapy and is associated with premature aging. The glycoprotein 120 (gp120) subunit of HIV-1 envelope sheds and can be detected in plasma, showing immunomodulatory properties even in the absence of detectable viremia. We evaluated whether plasma soluble gp120 (sgp120) and a family of gp120-specific anti-cluster A antibodies, linked to CD4 depletion in vitro, contribute to chronic inflammation, immune dysfunction, and subclinical cardiovascular disease in participants of the Canadian HIV and Aging Cohort Study with undetectable viremia.<h4>Methods</h4>Cross-sectional assessment of sgp120 and anti-cluster A antibodies was performed in 386 individuals from the The Journal of infectious diseasesPlasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia.PMC10938206UM1 AI164562R01 AI129769R01 AI148379UM1 AI164560R01 AI150322R01 AI174908R01 AI176531R01 AG054324R01 AI116274Maldarelli FKaufmann DETolbert WDClark ASylla MBaril JGBenlarbi MGendron-Lepage GFinzi ARichard JDuerr RDurand MVerly MMFromentin RTurcotte ITremblay CPazgier MChomont NChartrand-Lefebvre CBegin PTrottier SPrevost JMessier-Peet MMothes WBourassa CTrottier BGuertin CEl-Far MfalsePlasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia.<h4>Background</h4>Chronic inflammation persists in some people living with human immunodeficiency virus (HIV) during antiretroviral therapy and is associated with premature aging. The glycoprotein 120 (gp120) subunit of HIV-1 envelope sheds and can be detected in plasma, showing immunomodulatory properties even in the absence of detectable viremia. We evaluated whether plasma soluble gp120 (sgp120) and a family of gp120-specific anti-cluster A antibodies, linked to CD4 depletion in vitro, contribute to chronic inflammation, immune dysfunction, and subclinical cardiovascular disease in participants of the Canadian HIV and Aging Cohort Study with undetectable viremia.<h4>Methods</h4>Cross-sectional assessment of sgp120 and anti-cluster A antibodies was performed in 386 individuals from the 2024-01-01T00:00:00Z2024 Mar2026-06-24T03:09:37.858Z2026-06-24T03:06:26.637ZS-EPMC109382063803585410.1093/infdis/jiad503