{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mylona E"],"funding":["NIAID NIH HHS","Wellcome Trust","Trust","National Institutes of Allergy and Infectious Diseases"],"pagination":["833-844"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10938218"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["229(3)"],"pubmed_abstract":["<h4>Background</h4>Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi A, is a major public health problem in low- and middle-income countries. Moderate sensitivity and scalability of current methods likely underestimate enteric fever burden. Determining the serological responses to organism-specific antigens may improve incidence measures.<h4>Methods</h4>Plasma samples were collected from blood culture-confirmed enteric fever patients, blood culture-negative febrile patients over the course of 3 months, and afebrile community controls. A panel of 17 Salmonella Typhi and Paratyphi A antigens was purified and used to determine antigen-specific antibody responses by indirect ELISAs.<h4>Results</h4>The antigen-specific longitudinal antibody responses were comparable betw"],"journal":["The Journal of infectious diseases"],"pubmed_title":["The Identification of Enteric Fever-Specific Antigens for Population-Based Serosurveillance."],"pmcid":["PMC10938218"],"funding_grant_id":["R01 AI134814","215515/Z/19/Z"],"pubmed_authors":["Mylona E","Charles RC","Tran Vu Thieu N","Trinh Van T","Nguyen Ngoc Minh C","Parry CM","Dongol S","Tran Tuan A","Russell P","Karkey A","Baker S","Ho Ngoc Dan T","Hefele L","Basnyat B","Voong Vinh P"],"additional_accession":[]},"is_claimable":false,"name":"The Identification of Enteric Fever-Specific Antigens for Population-Based Serosurveillance.","description":"<h4>Background</h4>Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi A, is a major public health problem in low- and middle-income countries. Moderate sensitivity and scalability of current methods likely underestimate enteric fever burden. Determining the serological responses to organism-specific antigens may improve incidence measures.<h4>Methods</h4>Plasma samples were collected from blood culture-confirmed enteric fever patients, blood culture-negative febrile patients over the course of 3 months, and afebrile community controls. A panel of 17 Salmonella Typhi and Paratyphi A antigens was purified and used to determine antigen-specific antibody responses by indirect ELISAs.<h4>Results</h4>The antigen-specific longitudinal antibody responses were comparable betw","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-14T20:56:30.906Z","creation":"2026-06-24T03:06:10.666Z"},"accession":"S-EPMC10938218","cross_references":{"pubmed":["37403670"],"doi":["10.1093/infdis/jiad242"]}}