biostudies-literatureMylona ENIAID NIH HHSWellcome TrustTrustNational Institutes of Allergy and Infectious Diseases833-844https://www.ebi.ac.uk/biostudies/studies/S-EPMC10938218biostudies-literatureUnknown229(3)<h4>Background</h4>Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi A, is a major public health problem in low- and middle-income countries. Moderate sensitivity and scalability of current methods likely underestimate enteric fever burden. Determining the serological responses to organism-specific antigens may improve incidence measures.<h4>Methods</h4>Plasma samples were collected from blood culture-confirmed enteric fever patients, blood culture-negative febrile patients over the course of 3 months, and afebrile community controls. A panel of 17 Salmonella Typhi and Paratyphi A antigens was purified and used to determine antigen-specific antibody responses by indirect ELISAs.<h4>Results</h4>The antigen-specific longitudinal antibody responses were comparable betwThe Journal of infectious diseasesThe Identification of Enteric Fever-Specific Antigens for Population-Based Serosurveillance.PMC10938218R01 AI134814215515/Z/19/ZMylona ECharles RCTran Vu Thieu NTrinh Van TNguyen Ngoc Minh CParry CMDongol STran Tuan ARussell PKarkey ABaker SHo Ngoc Dan THefele LBasnyat BVoong Vinh PfalseThe Identification of Enteric Fever-Specific Antigens for Population-Based Serosurveillance.<h4>Background</h4>Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi A, is a major public health problem in low- and middle-income countries. Moderate sensitivity and scalability of current methods likely underestimate enteric fever burden. Determining the serological responses to organism-specific antigens may improve incidence measures.<h4>Methods</h4>Plasma samples were collected from blood culture-confirmed enteric fever patients, blood culture-negative febrile patients over the course of 3 months, and afebrile community controls. A panel of 17 Salmonella Typhi and Paratyphi A antigens was purified and used to determine antigen-specific antibody responses by indirect ELISAs.<h4>Results</h4>The antigen-specific longitudinal antibody responses were comparable betw2024-01-01T00:00:00Z2024 Mar2026-07-14T20:56:30.906Z2026-06-24T03:06:10.666ZS-EPMC109382183740367010.1093/infdis/jiad242