biostudies-literatureNore KGResearch Council Of NorwayUniversity of OsloOslo University HospitalOlav Thon Foundation888-897https://www.ebi.ac.uk/biostudies/studies/S-EPMC10938220biostudies-literatureUnknown229(3)<h4>Background</h4>Current tuberculosis treatment regimens could be improved by adjunct host-directed therapies (HDT) targeting host responses. We investigated the antimycobacterial capacity of macrophages from patients with tuberculosis in a phase 1/2 randomized clinical trial (TBCOX2) of the cyclooxygenase-2 inhibitor etoricoxib.<h4>Methods</h4>Peripheral blood mononuclear cells from 15 patients with tuberculosis treated with adjunctive COX-2i and 18 controls (standard therapy) were collected on day 56 after treatment initiation. The ex vivo capacity of macrophages to control mycobacterial infection was assessed by challenge with Mycobacterium avium, using an in vitro culture model. Macrophage inflammatory responses were analyzed by gene expression signatures, and concentrations of cytokThe Journal of infectious diseasesThe Cyclooxygenase 2 Inhibitor Etoricoxib as Adjunctive Therapy in Tuberculosis Impairs Macrophage Control of Mycobacterial Growth.PMC109382202344932876962232552017009Bugge MFlo THTonby KJenum SDyrhol-Riise AMLouet CJorgensen MJNore KGGidon AfalseThe Cyclooxygenase 2 Inhibitor Etoricoxib as Adjunctive Therapy in Tuberculosis Impairs Macrophage Control of Mycobacterial Growth.<h4>Background</h4>Current tuberculosis treatment regimens could be improved by adjunct host-directed therapies (HDT) targeting host responses. We investigated the antimycobacterial capacity of macrophages from patients with tuberculosis in a phase 1/2 randomized clinical trial (TBCOX2) of the cyclooxygenase-2 inhibitor etoricoxib.<h4>Methods</h4>Peripheral blood mononuclear cells from 15 patients with tuberculosis treated with adjunctive COX-2i and 18 controls (standard therapy) were collected on day 56 after treatment initiation. The ex vivo capacity of macrophages to control mycobacterial infection was assessed by challenge with Mycobacterium avium, using an in vitro culture model. Macrophage inflammatory responses were analyzed by gene expression signatures, and concentrations of cytok2024-01-01T00:00:00Z2024 Mar2026-07-05T03:15:24.473Z2026-07-05T03:11:20.828ZS-EPMC109382203772147010.1093/infdis/jiad390