biostudies-literatureUnknown9(5)Lee PH<h4>Importance</h4>Although intravascular ultrasonography (IVUS) guidance promotes favorable outcomes after percutaneous coronary intervention (PCI), many catheterization laboratories worldwide lack access.<h4>Objective</h4>To investigate whether systematic implementation of quantitative coronary angiography (QCA) to assist angiography-guided PCI could be an alternative strategy to IVUS guidance during stent implantation.<h4>Design, setting, and participants</h4>This randomized, open-label, noninferiority clinical trial enrolled adults (aged ≥18 years) with chronic or acute coronary syndrome and angiographically confirmed native coronary artery stenosis requiring PCI. Patients were enrolled in 6 cardiac centers in Korea from February 23, 2017, to August 23, 2021, and follow-up occurred thrJAMA cardiology428-435https://www.ebi.ac.uk/biostudies/studies/S-EPMC10938248biostudies-literatureQuantitative Coronary Angiography vs Intravascular Ultrasonography to Guide Drug-Eluting Stent Implantation: A Randomized Clinical Trial.PMC10938248Shin YJPark MHChoi SYShin YHGUIDE-DES Trial Research GroupBaek JChae MKKim TOKLee JSNam JWKang HKim SBKuk IKJeong HPyo GYLee MSKim JHChoi YWLee YWHan JYYun HYCho MSHong SJSong MULee PHSong JMSong JGLee CWPark KJYoon YSLee JYoon YWPark SWKim AKLee DOKim YHBea HSOh SJKim HYKim MHKim MJLee HJJun SKKang SJChung TKim TWKim TYPark JHKim HJRoh JSLee SHYu IAKang JWKim HSLee JYPark JSKim THKim GWLee SYLee SWYoon SCJung SfalseQuantitative Coronary Angiography vs Intravascular Ultrasonography to Guide Drug-Eluting Stent Implantation: A Randomized Clinical Trial.<h4>Importance</h4>Although intravascular ultrasonography (IVUS) guidance promotes favorable outcomes after percutaneous coronary intervention (PCI), many catheterization laboratories worldwide lack access.<h4>Objective</h4>To investigate whether systematic implementation of quantitative coronary angiography (QCA) to assist angiography-guided PCI could be an alternative strategy to IVUS guidance during stent implantation.<h4>Design, setting, and participants</h4>This randomized, open-label, noninferiority clinical trial enrolled adults (aged ≥18 years) with chronic or acute coronary syndrome and angiographically confirmed native coronary artery stenosis requiring PCI. Patients were enrolled in 6 cardiac centers in Korea from February 23, 2017, to August 23, 2021, and follow-up occurred thr2024-01-01T00:00:00Z2024 May2026-06-01T05:43:28.34Z2025-04-04T09:07:30.845ZS-EPMC109382483847791310.1001/jamacardio.2024.0059