{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kumar AV"],"funding":["NIA NIH HHS","NIH HHS"],"pagination":["eabj1604"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10938577"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(13)"],"pubmed_abstract":["Altered nucleolar and ribosomal dynamics are key hallmarks of aging, but their regulation remains unclear. Building on the knowledge that the conserved nuclear export receptor Exportin 1 (XPO-1/XPO1) modulates proteostasis and life span, we systematically analyzed the impact of nuclear export on protein metabolism. Using transcriptomic and subcellular proteomic analyses in nematodes, we demonstrate that XPO-1 modulates the nucleocytoplasmic distribution of key proteins involved in nucleolar dynamics and ribosome function, including fibrillarin (FIB-1/FBL) and RPL-11 (RPL11). Silencing <i>xpo-1</i> led to marked reduction in global translation, which was accompanied by decreased nucleolar size and lower fibrillarin levels. A targeted screen of known proteostatic mediators revealed that the "],"journal":["Science advances"],"pubmed_title":["Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP."],"pmcid":["PMC10938577"],"funding_grant_id":["R01 AG051810","R00 AG042494","P40 OD010440","R21 AG068922"],"pubmed_authors":["Rogers AN","Kang T","Thakurta TG","Ng C","Kumar AV","Larsen MR","Lapierre LR"],"additional_accession":[]},"is_claimable":false,"name":"Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP.","description":"Altered nucleolar and ribosomal dynamics are key hallmarks of aging, but their regulation remains unclear. Building on the knowledge that the conserved nuclear export receptor Exportin 1 (XPO-1/XPO1) modulates proteostasis and life span, we systematically analyzed the impact of nuclear export on protein metabolism. Using transcriptomic and subcellular proteomic analyses in nematodes, we demonstrate that XPO-1 modulates the nucleocytoplasmic distribution of key proteins involved in nucleolar dynamics and ribosome function, including fibrillarin (FIB-1/FBL) and RPL-11 (RPL11). Silencing <i>xpo-1</i> led to marked reduction in global translation, which was accompanied by decreased nucleolar size and lower fibrillarin levels. A targeted screen of known proteostatic mediators revealed that the ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-07-15T00:39:43.8Z","creation":"2026-06-27T03:05:38.68Z"},"accession":"S-EPMC10938577","cross_references":{"pubmed":["35363528"],"doi":["10.1126/sciadv.abj1604"]}}