{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim HJ"],"funding":["NIA NIH HHS"],"pagination":["93-109"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10939110"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(1)"],"pubmed_abstract":["Myeloid ecotropic virus insertion site 1 (<i>MEIS1</i>) is a HOX co-factor necessary for organ development and normal hematopoiesis. Recently, <i>MEIS1</i> has been linked to the development and progression of various cancers. However, its role in gliomagenesis particularly on glioma stem cells (GSCs) remains unclear. Here, we demonstrate that <i>MEIS1</i> is highly upregulated in GSCs compared to normal, and glioma cells and to its differentiated counterparts. Inhibition of <i>MEIS1</i> expression by shRNA significantly reduced GSC growth in both <i>in vitro</i> and <i>in vivo</i> experiments. On the other hand, integrated transcriptomics analyses of glioma datasets revealed that <i>MEIS1</i> expression is correlated to cell cycle-related genes. Clinical data analysis revealed that <i>MEIS1</i> expression is elevated in high-grade gliomas, and patients with high <i>MEIS1</i> levels have poorer overall survival outcomes. The findings suggest that <i>MEIS1</i> is a prognostic biomarker for glioma patients and a possible target for developing novel therapeutic strategies against GBM."],"journal":["Animal cells and systems"],"pubmed_title":["The impact of <i>MEIS1</i> TALE homeodomain transcription factor knockdown on glioma stem cell growth."],"pmcid":["PMC10939110"],"funding_grant_id":["R01 AG068179","R56 AG082796"],"pubmed_authors":["Lee S","Jeon YJ","Beck S","Kim SH","Kim HJ","Batara DC"],"additional_accession":[]},"is_claimable":false,"name":"The impact of <i>MEIS1</i> TALE homeodomain transcription factor knockdown on glioma stem cell growth.","description":"Myeloid ecotropic virus insertion site 1 (<i>MEIS1</i>) is a HOX co-factor necessary for organ development and normal hematopoiesis. Recently, <i>MEIS1</i> has been linked to the development and progression of various cancers. However, its role in gliomagenesis particularly on glioma stem cells (GSCs) remains unclear. Here, we demonstrate that <i>MEIS1</i> is highly upregulated in GSCs compared to normal, and glioma cells and to its differentiated counterparts. Inhibition of <i>MEIS1</i> expression by shRNA significantly reduced GSC growth in both <i>in vitro</i> and <i>in vivo</i> experiments. On the other hand, integrated transcriptomics analyses of glioma datasets revealed that <i>MEIS1</i> expression is correlated to cell cycle-related genes. Clinical data analysis revealed that <i>MEIS1</i> expression is elevated in high-grade gliomas, and patients with high <i>MEIS1</i> levels have poorer overall survival outcomes. The findings suggest that <i>MEIS1</i> is a prognostic biomarker for glioma patients and a possible target for developing novel therapeutic strategies against GBM.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-27T03:10:39.545Z","creation":"2026-06-27T03:05:40.888Z"},"accession":"S-EPMC10939110","cross_references":{"pubmed":["38487309"],"doi":["10.1080/19768354.2024.2327340"]}}